CCTV News: Li Bin, male, born in May, 1950, Han nationality, party member of CPC, section chief of Shanghai Electric Hydraulic Pneumatic Co., Ltd.

　　Li Bin has successively completed 55 new product development projects, 201 process research projects, more than 1,500 NC machining process programming projects, directly created economic benefits of more than 8.3 million yuan, designed 184 cutters, and made 82 pairs of self-made improved fixtures and fixtures, which saved high costs for enterprises and won many patents.

　　Honors won: second prize of national scientific and technological progress, four consecutive national model workers, Chinese skill award, top ten national models of high-skilled talents, Shanghai Mayor’s quality award, and the first Shanghai craftsman.

　　I. Resume

　　Li Bin, male, born in 1960, graduated from technical school in 1980 and entered Shanghai Hydraulic Pump Factory as a junior worker. In order to better contribute to the development of the enterprise, he aims at the continuous charging of demand, what is missing in the post, what he studies, and what the enterprise needs, he will make up. Through self-study, he completed his high school studies. After three years of spare-time study, he obtained a junior college degree in mechanical engineering from Shanghai TV University. In the summer of 1998, Li Bin obtained a bachelor’s degree in mechanical and electronic engineering from shanghai second polytechnic university, and obtained a bachelor’s certificate and a bachelor’s degree.

　　Li Bin is now the section chief of the CNC workshop of Shanghai Electric Hydraulic Pneumatic Co., Ltd., a senior engineer, a senior technician, a chief technician of Shanghai Electric (Group) Corporation, and one of the most influential labor models since the founding of New China. He has won the first top ten workers’ inventors in Shanghai, outstanding professional and technical talents in Shanghai, Chinese Skills Award, national knowledge worker model, national top ten high-skilled talents model, and enjoyed the special allowance of the State Council experts; In 2011, he won the first prize of national model individual and expert in technological innovation of machinery industry workers and outstanding technological innovation achievements of Shanghai workers; In 2013, he was recognized as the chief gold medal worker of the national mechanical metallurgy building materials system. Li Bin is a representative of the 11th, 12th and 13th National People’s Congress and the 16th, 17th and 19th National People’s Congress of the Communist Party of China (CPC). Delegate to the 13th, 14th, 15th and 16th National Congresses of the All-China Federation of Trade Unions. Shanghai Electric Group established the first school named after ordinary workers in China — — Shanghai Electric Li Bin Technician College. Under the background of "innovation-driven, transformational development", Li Bin used his actions to change the status quo that China’s hydraulic technology is still at a low level in the world, and the basic parts of high-end construction machinery and equipment are completely dependent on imports.

　　Second, the work performance

　　1. Personal moral integrity

　　A tree is a painting, and a forest is a landscape. Li Bin always believes that no matter how great one’s personal skills are, it is only a single strength. Only by cultivating and bringing out more "smart workers" can we effectively promote enterprise development and social development.

　　Through Li Bin Studio as the carrier, Li Bin trained and trained a group of technical backbones who love the enterprise, love their jobs, have dedication, can study hard and work hard. Through the training of key projects, many studio members have made outstanding achievements in their jobs.

　　2. Excellent professional ability

　　Since 2012, Li Bin has led the members of the studio and made many breakthroughs in the localization project of A6V variable motor:

　　2.1 A6V series of new product development projects

　　The project has completed seven series, including A6V28, A6V55, A6V80, A6V107, A6V160, A6V200 and A6V250, including new product development and small batch production, and the performance of the products has basically reached the level of similar products of Rexroth.

　　2.2 A6V series cylinder measurement key project

　　According to the characteristics of NC machine tool processing and the measuring principle of three-coordinate measuring instrument, a set of simple and practical coaxiality measuring die is designed.

　　This measurement method is simple and reliable. Now this spherical measuring mold has been manufactured and put into use. The coaxiality between the axis of the seven holes in the cylinder body and the spherical surface can be controlled within 0.02 mm. The quality of the cylinder body is greatly improved.

　　2.3 Manufacturing Project of Assembly Line of Inclined Shaft Piston Pump

　　Through the analysis of the upper and lower stations and fixture positioning, the project organized the improvement of the assembly line. After the trial assembly of the products, the assembly line was gradually improved, which achieved obvious improvement effects: through the active participation and cooperation of various departments, the design and manufacture of the assembly line of the inclined shaft piston pump were completed, and the quality and efficiency of production were greatly improved.

　　2.4 Design and application of casting mould for motor cover and shell of variable speed motor

　　The purpose of the project is to solve the problems of looseness and sand holes in the casting of the motor cover and shell of variable speed motor.

　　According to the characteristics of the product, the casting mold was redesigned and made. The metal mold was used for assembly line casting, and the whole casting process and various parameters were controlled by computer. It plays a very important role in improving product quality and reducing scrap rate.

　　Through a series of project innovations, such as A6V series new product development project, A6V series cylinder measurement tackling key problems project, inclined shaft piston pump assembly line manufacturing project and variable motor motor cover and shell casting mold design and application project, A6V series inclined shaft hydraulic variable motor has reached the international advanced and domestic leading level.

　　3. Outstanding work performance

　　High-pressure axial piston pump/motor is an important component of hydraulic system. The low level of basic technology in China leads to the domestic hydraulic technical performance and reliability far behind that in Germany, which has become a bottleneck restricting the development of main engine. The development of domestic high-end construction machinery mainframe industry depends entirely on imported hydraulic components, and the national military products are also greatly affected.

　　In order to revitalize the hydraulic technology in China, Li Bin took the initiative to propose and undertake the innovative research project of "Key Technologies for Localization of High-pressure Axial Piston Pump/Motor", with the goal of increasing the maximum pressure from 25MPa to 40MPa and the maximum rotation speed from 1,500 r/min to 6,000 r/min, so as to meet the performance requirements of high-end hosts. He led the project team, and through the design and application of 11 technological innovations, laid the foundation for the key technical indicators of the products to reach the international advanced level. Through the third-party type test, the main technical indicators have completely reached the German peak pressure and the highest speed. The appraisal conclusion of Shanghai Economic and Information Commission on "Key Technologies of Localization of High-pressure Axial Piston Pump/Motor" is: "The project has reached the domestic leading and international advanced level in general." The project won the second prize of National Science and Technology Progress Award and the first prize of China Machinery Industry Science and Technology Award.

　　In recent years, Li Bin led the team to make a breakthrough in the project of high-pressure axial piston pump/motor, and further developed the more advanced A6V series variable motor domestically. A6V series oblique-shaft hydraulic variable-speed motors are widely used in the construction machinery industry at present, for example, they can be used to hoist and rotate crawler cranes, and they are important basic parts of construction machinery. However, A6V series inclined-axis hydraulic variable-speed motors used in China’s construction machinery industry have long relied on imports and are basically monopolized by international giants in Europe and America.

　　Due to some domestic fields, such as metal materials, heat treatment technology of metal materials, high precision and high precision machining technology, there is still a certain gap compared with the international advanced level. The A6V products produced by us have many problems, such as many early failures, unstable processing quality and low qualified rate of parts processing. In order to change these technical problems of A6V products, Li Bin Studio took A6V product technical research as "Model Worker Innovation Studio Project". After the completion of the project, the annual sales revenue of variable displacement pump/motor series products related to this key project exceeded 6 million yuan.

　　The breakthrough of key technologies has enabled China to truly possess the internationally advanced manufacturing technology of variable speed motors. By tackling the key problems of localization, we truly have the international advanced manufacturing technology of hydraulic components, which has practical and long-term significance for changing the backward situation of basic hydraulic components in China.

　　Third, the economic and social benefits achieved

　　1. Economic benefits

　　In 2015 and 2016, due to the influence of macro-control, the construction machinery industry was not prosperous, and the sales of major domestic main engine plants all dropped significantly, but our variable displacement pump/motor products still achieved sales of 7.57 million yuan and 6.14 million yuan respectively. Since the end of 2016, with the gradual deepening of the national "One Belt, One Road" strategy, the construction machinery industry has gradually stepped out of the trough. Especially since January 2017, the supply of hydraulic pumps/motors produced by our company has been in short supply in the construction machinery market in China, and the sales volume has greatly increased compared with previous years. In 2017, the sales volume of products related to key projects was 9.213 million yuan, which achieved good economic benefits for enterprises.

　　2. Social benefits

　　2.1 Breakthrough of key technologies

　　The breakthrough of key technologies has enabled China to truly possess internationally advanced A6V series product manufacturing technology. Rexroth’s hydraulic technology has been in the leading position in the world for a long time. By tackling key problems in localization, we have truly advanced international hydraulic component manufacturing technology, which has practical and long-term significance for changing the backward situation of basic hydraulic components in China. Breaking Rexroth’s technical monopoly, realizing the full localization of high-end hydraulic components, greatly reducing the supporting cost of the main engine, saving the national foreign exchange and promoting the national "Belt and Road" strategy have great social benefits.

　　2.2 Product performance and reliability have been greatly improved.

　　With the improvement of product performance and reliability, the company’s products have been designated as supporting products for military industry, which are used for supporting 09Ⅲ and 09Ⅳ steering gear, a new generation of self-propelled gun launchers and missile destroyers. The supporting products participated in the military parade of the 90th anniversary of the founding of the People’s Liberation Army in China at the end of July 2017, visited Hong Kong for the escort ship of the Liaoning carrier in July 2017, and went to the Gulf of Aden for escort operations and China naval parade in September 3, 2015.

Haikou, China Broadcasting Network, March 20 th Recently, Haikou Zhongsheng Lexus Automobile Sales & Service Co., Ltd. was suspected of increasing the price outside the price, which caused widespread concern after being exposed by the media. On the morning of March 20th, the reporter learned from Haikou Municipal Market Supervision Administration that the market supervision department planned to impose an administrative penalty of 450,000 yuan for the company’s price fraud that refused to fulfill its price commitment without justifiable reasons, and put it on the list of serious violations of law and dishonesty.

Haikou Zhongsheng Lexus 4S Store (photo by Yang Guangwang reporter Cai Wenjuan)

In January this year, Mr. Wang, a citizen, ordered a car in Haikou Zhongsheng Lexus 4S store (affiliated to Haikou Zhongsheng Lexus Automobile Sales and Service Co., Ltd.). After signing the contract and paying the deposit, the salesman asked for an additional service fee of 100,000 yuan as a condition for picking up the car. After being rejected by Mr. Wang, the salesperson unilaterally returned the car purchase deposit. After the competent departments of commerce, market supervision and other industries in Haikou intervened in the investigation, on March 14th, the 4S store issued an apology statement and dismissed the customer service manager involved.

Administrative Law Enforcement Detachment of Haikou Municipal Market Supervision Administration (photo by Yang Guangwang reporter Cai Wenjuan)

On March 20th, a notice that Haikou Municipal Market Supervision Administration was included in the list of serious violations of law and dishonesty (hereinafter referred to as the "notice") was circulated on the Internet. After verification by the reporter, it was confirmed as the relevant documents issued by Haikou Municipal Market Supervision Administration.

The "Notice" shows that Haikou Zhongsheng Lexus Automobile Sales & Service Co., Ltd. failed to fulfill its price commitment and put forward an unreasonable request to raise the price by 100,000 yuan beyond the agreed price. After the consumer Wang refused, he unilaterally returned the deposit. Haikou Zhongsheng Lexus Automobile Sales & Service Co., Ltd. is suspected of violating Item 4 of Article 14 of the Price Law of People’s Republic of China (PRC) and Item 3 of Article 2 and Item 5 of Article 19 of the Provisions on Clearly Marking Prices and Prohibiting Price Fraud, which constitutes a price fraud that refuses to fulfill the price commitment without justifiable reasons. According to Article 23 of the Provisions on Clearly Marking Prices and Prohibiting Price Fraud and Article 7 of the Provisions on Administrative Penalties for Price Violations, Haikou Municipal Market Supervision Administration intends to impose an administrative penalty of RMB 450,000 on Haikou Zhongsheng Lexus Automobile Sales & Service Co., Ltd..

According to Article 2, Paragraph 2, Item 1 and Article 9, Item 6 of the Measures for the Administration of Market Supervision and Management of Serious Violations of Law and Trustworthiness, it is now decided to include Haikou Zhongsheng Lexus Automobile Sales & Service Co., Ltd. in the list of serious violations of law and trustworthiness, publicize it to the public through the national enterprise credit information publicity system, and implement corresponding management measures. The inclusion period is three years from the date of inclusion.

On the morning of the same day, Yuan Renxiang, a case handler of the Administrative Law Enforcement Detachment of Haikou Municipal Market Supervision Administration, introduced in an interview that after receiving the case clue letter forwarded by Haikou Municipal Bureau of Commerce, Haikou Municipal Market Supervision Administration immediately organized the case handlers to go to the scene to investigate and collect evidence and issue handling opinions. During the period, the case-handling personnel collected complaints related to the 4S shop since 2019, and found no similar situation. At the same time, during the investigation, the case-handling personnel contacted Mr. Wang many times, but they failed to get in touch, which also caused certain difficulties in the investigation process.

The case-handling personnel were interviewed by reporters (photo by Yang Guangwang reporter Cai Wenjuan)

Yuan Renxiang said that at present, the relevant investigation results have come out, and the Haikou Municipal Market Supervision Administration has also issued a Notice, which was delivered to the person in charge of the enterprise involved on the evening of March 19.

Li Kexiong, the captain of the Fourth Brigade of the Market Supervision Administrative Law Enforcement Detachment of Haikou Municipal Market Supervision Administration, said that the case is still being processed. After the Notice is delivered to the enterprises involved, the enterprises have five working days to appeal. After 5 working days, if there are no other circumstances, the market supervision department will issue a "Penalty Decision" in accordance with relevant procedures.

The relevant person in charge of the office of Haikou Municipal Market Supervision Administration told the reporter that the market supervision department has not strictly defined the behavior of adding value-added service fees to some businesses. "Any fee must be clearly marked and the service content is clear. Sales staff should inform consumers in advance before charging, and consumers have the right to choose to accept or refuse. " The person in charge said.

The person in charge reminded consumers not to trust the verbal promises of the merchants when buying a car, but to sign a car purchase contract, pay attention to whether the terms of the car purchase contract are complete, clearly stipulate the necessary elements of the purchased car, and list the total price, payment method and time limit of the vehicle transaction, delivery method and time limit of the vehicle, as well as the handling of quality disputes and objections and the liability for breach of contract, so as to avoid the difficulty of proof when defending rights and earnestly safeguard their legitimate rights and interests.

(The original title is "Haikou Municipal Market Supervision Bureau intends to impose a fine of 450,000 yuan on Lexus 4S shop for" suspected price increase "and list it in the list of serious violations of law and trust")

The report of the 19th National Congress of the Communist Party of China proposed "cultivating new growth points and forming new kinetic energy in the fields of high-end consumption, innovation leading, green and low-carbon, sharing economy, modern supply chain and human capital services". This is the first time that the CPC Central Committee put forward the concept of modern supply chain, which indicates that the development of "modern supply chain" has officially risen to a national strategy. At present, China’s economy has changed from a high-speed growth stage to a high-quality development stage, and it is in the key period of changing the development mode, optimizing the economic structure and transforming the growth momentum. In order to achieve high-quality economic development and build a modern economic system, it is urgent to develop a modern supply chain, play an important role in boosting supply-side structural reform, promoting optimal allocation of resources and improving economic quality and efficiency, foster new growth points and new kinetic energy, and promote quality change, efficiency change and power change of economic development.

Characteristics and development trend of modern supply chain

Modern supply chain is a concept corresponding to the traditional supply chain. It refers to an organizational form that takes customer demand as the guide, takes data as the core element, and uses modern information technology and modern organizational methods to efficiently integrate, optimize and coordinate upstream and downstream enterprises and related resources, so as to realize efficient coordination in the whole process of product design, procurement, production, sales and service. Compared with the traditional supply chain, the modern supply chain has the characteristics and trends of digitalization, intelligence, platformization, service, greening and globalization.

(A) Digitalization and intelligence have become the remarkable features of modern supply chain.

The rapid development and application of modern information technology has promoted the development of supply chain to a new stage of smart supply chain which is deeply integrated with Internet and Internet of Things. Digitalization, networking and intelligence have become the remarkable features of modern supply chain. Digital empowerment endows the supply chain with new intelligent features of big data support, networked sharing and intelligent collaboration, which greatly improves the efficiency of supply chain collaboration and significantly reduces the cost of supply chain. According to the data, an effective digital supply chain as a whole can promote the income growth of enterprises by 10%, the procurement cost by 20% and the supply chain cost by 50%.

(B) Internet platform has become a new form of modern supply chain development.

With the deepening application of modern information technologies such as big data, Internet of Things, cloud computing, artificial intelligence, blockchain, etc. in the supply chain, the organizational form of modern supply chain has gradually extended from multinational corporations to platform-based organizations, and platformization has gradually become an important feature of modern supply chain development. The cross-industry, cross-regional and cross-border industrial supply chain platform with platform-based enterprises as the core realizes resource integration and complementary advantages by cooperating with different countries, different regions, different industries and different enterprises, and builds a close cooperative global supply chain network, realizing integrated supply chain operation, and radiating and driving more and more upstream and downstream enterprises to develop in the direction of scale, clustering and specialization. At the same time, the upstream and downstream related enterprises at different levels form a supply chain ecosystem with cross-border integration, platform sharing and common prosperity under the integration of supply chain platforms, and promote the evolution of platform-based organizations to ecological organizations.

(C) Supply chain service has become a new service industry.

The reform of modern information technology and the deepening and refinement of industrial division of labor have promoted the separation of upstream R&D, raw material procurement, design and downstream brand management, sales, logistics and other service links, promoted the rapid development of supply chain service outsourcing, and promoted the innovation of supply chain service format to become an important trend of modern supply chain development. At present, the number of enterprises providing specialized supply chain services in China is booming and the types are constantly enriched, and a number of integrated supply chain service platforms represented by Yi Yatong and Yi Datong have been formed.

(D) Green supply chain management has become the social responsibility of enterprises.

With global warming, environmental pollution and other major ecological and environmental problems becoming increasingly prominent, green and sustainable development has become a global topic. Under the concept of sustainable development, cross-country cross-regional cross-domain supply chains are gradually required to be sustainable and responsible for society and ecology. In 2015, the "green supply chain" entered the APEC issue and became one of the most concerned topics in the world. At present, many multinational companies regard "green supply chain" management as an important task of social responsibility, and incorporate sustainable development and environmental protection into supply chain management. For example, since 2011, Huawei has included the environmental search of the non-governmental organization Public Environmental Research Center (IPE) in the supplier audit list and self-inspection form, requiring suppliers with problems to rectify within a time limit and strive to build a green supply chain. In 2017, Huawei ranked sixth in the IPE green supply chain CITI index, and domestic enterprises ranked first.

(E) The global economy has entered the era of supply chain coordination.

With the development of economic globalization and the escalation of regional economic and trade agreements, supply chain management has also developed from cooperation among domestic enterprises to cooperation among regional or global enterprises. Especially with the development of Internet technology, the mode of division of labor in the world has changed from industrial division based on comparative advantage to supply chain division based on factor advantage, and multinational enterprises participating in global division of labor have formed a reciprocal interdependence. In recent years, influenced by the rise of trade protectionism and other factors, although the process of economic globalization has slowed down, the global value chain and supply chain division system have been formed, and the trend is irreversible. In the global supply chain coordination system, the trade and investment among countries in the world are increasingly interrelated and influenced each other. You have me and I have you, and the interests are blended and mutually beneficial.

The important role of modern supply chain in supply-side structural reform

Promoting supply-side structural reform is a major strategic deployment made by the CPC Central Committee with the Supreme Leader as the core to profoundly grasp the new global economic pattern and the general trend of China’s economic development. It is an innovative measure to solve the problems of imbalance between supply and demand and overcapacity in economic development and lead China’s high-quality economic development. As a bridge and link between the supply side and the demand side, modern supply chain is an important starting point for promoting the structural reform of the supply side in a market-oriented way. The development of modern supply chain is conducive to the use of advanced supply chain management technology and mode to replace the inefficient and extensive operation mode in the past, promote cost reduction and efficiency improvement, optimize supply structure, supply quality and supply efficiency, and promote high-quality economic development.

(A) is conducive to achieving the goal of cost reduction

For a long time, China’s logistics cost is high. In 2017, the ratio of total social logistics cost to GDP in China was 14.6%, which was 3.4 percentage points lower than that in 2012, but still 5-6 percentage points higher than that in developed countries such as the United States. At present, China is at the critical stage of the transition from high cost and high growth to low cost and medium-high growth. With the deepening of supply-side structural reform, "cost reduction" has entered the stage of tackling difficulties. To further reduce enterprise costs, there must be new ways and new ideas. Modern supply chain can effectively reduce enterprise operating costs and transaction costs by integrating all kinds of resources, optimizing internal and external business processes, and strengthening the whole process and whole chain collaborative management from R&D and design, manufacturing to after-sales service. By integrating and optimizing the supply chain, Haier promoted business process reengineering, which reduced the enterprise inventory by 33%, manufacturing cost by 10%, management cost by 6% and timely delivery rate by 35%.

(B) conducive to improving the quality and efficiency of supply.

Judging from the stage of economic development, since China’s industrialization process has entered the middle and late stage of industrialization, the gap between the general technical level and advanced countries has been greatly narrowed. In this case, to improve the supply structure and create new supply, the most important thing is to improve the supply efficiency. The key to improving efficiency lies in promoting the optimal allocation and integrated innovation of factor resources by market-oriented means. With the help of information technologies such as Internet, cloud computing, big data and artificial intelligence, modern supply chain promotes enterprises to make timely and accurate market reactions, make rational decisions, arrange production in an orderly manner, and get through all links from front-end design, production to circulation and final consumption, greatly improving production efficiency and circulation efficiency, and promoting accurate matching between supply and demand and industrial transformation and upgrading. According to McKinsey’s research report, China’s labor productivity can be increased by 15%-30% by promoting operational transformation through supply chain and other means. ZARA, an internationally renowned chain retail brand, can grasp the sales situation and inventory changes of every store in the world at any time through an efficient supply chain system, and respond quickly to the market consumption trend, and complete the planning and design of new clothes to the factory within one week.

(C) conducive to the cultivation of new economic kinetic energy

At present, China’s economy has changed from a high-speed growth stage to a high-quality development stage, and it is in the key period of changing the development mode, optimizing the economic structure and transforming the growth momentum. Affected by the increasingly complex and changeable international economic situation, China’s economy is facing shrinking exports, overcapacity in traditional industries and bottlenecks in the development of traditional kinetic energy. It is urgent to deepen structural reform on the supply side and cultivate new kinetic energy. Modern supply chain, through resource integration and optimal allocation, is conducive to promoting the development of new formats and new models and promoting the transformation and upgrading of traditional industries, and is a new driving force and engine for economic development. On the one hand, in the process of integrated development of manufacturing industry and service industry, by promoting cross-border integration, optimization and innovation of supply chain, new services and business models can be generated, specialized supply chain services can be formed, and new economic growth points can be cultivated. On the other hand, cultivating new kinetic energy of economic development should not only focus on the development of new formats, new industries and new models, but also attach importance to the transformation and upgrading of traditional industries. In the process of upgrading traditional industries, by transforming the traditional supply chain and realizing the digitalization, networking and intelligent development of the supply chain, it can promote the transformation and upgrading of traditional industries and form new kinetic energy for economic development.

(4) It is conducive to filling the shortcomings of industrial development.

In the international division of labor system, China has long been "locked" in the low-end link of the global value chain led by multinational companies in developed countries. In recent years, under the influence of a new round of scientific and technological revolution and the implementation of the "re-industrialization" strategy in Europe and America, the international economic and trade pattern has undergone fundamental changes, and international industrial transfer has formed a trend of "high-end links returning to developed countries" and "low-end links transferring to lower-cost areas such as Southeast Asia, South Asia and Africa", which has promoted the accelerated reconstruction of global value chains led by multinational companies from developed countries. As a result, the expansion space for China to continue to participate in the global value chain by taking advantage of traditional advantages is getting smaller and smaller, and the original model of global value chain development dominated by developed countries is unsustainable. It is urgent to explore new development models and promote the industry to extend to the middle and high end of the global value chain. By organically integrating all links in the global value chain, modern supply chain ensures the seamless connection of logistics and finance related to industries, promotes the coordinated development of upstream and downstream manufacturing industries, and gradually improves the front-end design, R&D, procurement and back-end brand, logistics, marketing, finance and other service capabilities, which is beneficial for Chinese enterprises to get rid of their dependence on multinational companies in developed countries, promote the manufacturing industry to move towards the middle and high end, and build a world-class advanced manufacturing cluster.

Developing modern supply chain to help supply-side structural reform

To give full play to the role of modern supply chain in promoting supply-side structural reform, we should take market demand as the guide and modern information technology as the support, accelerate the in-depth application of modern supply chain in various industries and fields, build and optimize the supply chain systems of key cities, industries and enterprises, cultivate new formats and models for supply chain development, promote the digital, platform-based, service-oriented and green development of supply chain, form new economic growth points and new kinetic energy, and promote the innovative development, transformation and upgrading of the real economy.

(1) Cultivate a digital and professional supply chain platform to create new kinetic energy for economic development.

Digital and professional supply chain platform is the core force to promote the development of modern supply chain. It is necessary to conform to the development trend of digital economy, accelerate the application of information technologies such as Internet of Things, cloud computing, big data and blockchain in supply chain management, encourage powerful enterprises to build a digital and professional supply chain platform, build a smart supply chain system with big data support, networked sharing and intelligent collaboration, realize the whole system, full life cycle and all-round linkage with software and hardware manufacturing resources of upstream and downstream enterprises, improve the informatization, networking and intelligence level of upstream and downstream enterprises in the supply chain, and improve the rapid response speed.

Digital and specialized supply chain platforms should focus on cultivating three categories:

The first is to cultivate a comprehensive service platform for the supply chain. Encourage third-party logistics enterprises and foreign trade enterprises to transform into supply chain service enterprises, build a comprehensive supply chain service platform, integrate high-quality resources from different regions, industries and enterprises, comprehensively cover the upstream procurement network, the midstream warehousing circulation network and the downstream sales service network of the industrial chain, and provide supply chain integration services integrating transactions, financing, settlement, logistics distribution, import and export agents, brand cultivation and marketing promotion, so as to realize resource integration, complementary advantages and coordinated sharing between the upstream and downstream of the industrial chain.

The second is to cultivate a collaborative supply chain platform for production and marketing. Guided by the demand side, enterprises are encouraged to explore and develop a collaborative supply chain platform for production and marketing, build a large-scale customized supply chain and an intelligent manufacturing supply chain, drive the supply, procurement, stocking and distribution system with accurate demand forecasting, strengthen the synergy of supply chains, improve the response speed and synergy level of raw material procurement, production, logistics and distribution, and promote the integrated development of production and marketing.

The third is to cultivate a supply chain financial service platform. Encourage supply chain service enterprises and related logistics enterprises to cooperate with banks and e-commerce platforms, build digital, intelligent and visual financial services based on the risk control and credit system formed by data sharing of all parties involved, provide online credit, factoring, guarantee, settlement, wealth management and other comprehensive financial services for small and medium-sized enterprises in the upstream and downstream of the supply chain, reduce supply chain financing costs and improve the efficiency of supply chain financial services.

(B) Promote the innovation and application of industrial cluster supply chain, and improve the industrial supply chain system.

Since the reform and opening up, China has set up a number of industrial parks, such as economic and technological development zones, high-tech industrial parks and customs bonded zones, which have effectively promoted the development of industrial agglomeration in China, and formed a number of influential industrial clusters at home and abroad in the Yangtze River Delta, Pearl River Delta and Bohai Rim. However, in recent years, with the rising factor cost and the implementation of "internet plus Strategy", the problems faced by traditional industrial clusters in China, such as squeezed development space, imperfect industrial chain and weak competitiveness of clusters, have become increasingly prominent. It is urgent to strengthen the innovation and application of supply chain in industrial clusters, effectively improve industrial synergy and promote industrial transformation and upgrading. Therefore, on the one hand, it is necessary to build various supply chain collaborative platforms around the common needs of enterprises in industrial clusters in product design, material procurement, manufacturing, inspection and testing, logistics and marketing, and improve the industrial supply chain system through collaborative design, collaborative procurement, collaborative manufacturing, collaborative logistics and financial services, so as to promote the mutual complement and common development of online platforms and offline industrial clusters. On the other hand, it is necessary to give full play to the supply chain resource integration and service capabilities of leading enterprises in different industrial clusters, and design, plan, control and optimize the logistics, business flow, information flow and capital flow in the supply chain, so as to promote the coordinated development of upstream and downstream enterprises and rapidly improve the innovation and application level of the supply chain.

(C) Promote enterprises to implement green supply chain management and promote industrial green transformation and upgrading.

Promoting enterprises to implement green supply chain management and build a green supply chain system is the core meaning of practicing the concept of green development and deepening the structural reform of supply side. At present, the development of China’s green supply chain is still in the initial exploration stage. Compared with developed countries, the awareness of green management of Chinese enterprises is relatively weak, and the environmental pollution caused by various logistics activities in the supply chain is still serious. Take the packaging recovery rate as an example, there is a big gap between China and developed countries. The data shows that in 2017, the actual recovery rate of cardboard and plastics in China’s express delivery industry was less than 10%, and the overall recovery rate of packaging was less than 20%. Most of these packages were directly sent to landfill sites, which brought great pressure to the urban environment. In some developed countries, the recycling rate of cardboard packaging is about 45%, while the recycling rate of plastic packaging is about 25%.

Therefore, we should take industry and enterprises as the core, speed up the construction of a resource-saving and environment-friendly procurement, production, marketing, recycling and logistics system, formulate strict green product standards, explore the establishment of a unified green product standard, certification and labeling system, and realize the green development of the supply chain. On the one hand, we should take enterprises as the core, implement green supply chain management, encourage enterprises to give priority to purchasing and using energy-saving and water-saving equipment, promote clean production and green manufacturing, produce green energy-saving and environmental protection products, expand the supply of green products and improve the quality of green products. On the other hand, it is necessary to build a green supply chain with key industries as the core and promote industrial transformation and upgrading. In agriculture, we should use green technology to protect and improve the agricultural ecological chain, establish and expand the green supply chain of agricultural products, vigorously develop agricultural circular economy, promote the organic and pollution-free development of agriculture, and realize the sustainable growth of agricultural economy. In the manufacturing industry, we will promote green supply chain management in industries such as electronic appliances, automobiles, steel and textiles, and promote the formation of an industrial supply chain with high technology content, low resource consumption and less environmental pollution through green transformation of product design, raw material selection, manufacturing process, logistics, recycling and final disposal, and promote the green transformation and upgrading of the industry. In the service industry, we should focus on the circulation link closely related to production and consumption, adopt modern information technology and management methods to transform the traditional circulation mode, continue to implement demonstration projects such as green procurement, green marketing and green shopping malls, encourage express delivery enterprises to develop recyclable packaging materials, and promote"Green Circulation Revolution" guides consumers to consume green.

(D) Promote the integration of advantageous industries into the global supply chain and help "de-capacity" and "fill shortcomings"

Seize the opportunity of the "Belt and Road" construction and international capacity cooperation, actively promote enterprises to deeply participate in global industrial chain and value chain competition, cooperation and division of labor, deeply integrate the global supply chain system, promote the "going out" of domestic excess capacity, actively build a global supply chain led by China enterprises, and enhance the position of China industry in the global value chain. First, combined with the actual situation of industrialization stage and industrial development in countries and regions along the Belt and Road, we will accelerate labor-intensive industries such as clothing, shoes and hats and capital-intensive industries with overcapacity such as steel, coal and cement to help "de-capacity". The second is to promote the transfer of advantageous technology-intensive industries such as electronic information and equipment manufacturing to countries along the route. By promoting the in-depth cooperation of the upstream, middle and downstream industrial chains, the "Belt and Road" industrial cooperation will be extended from the processing and manufacturing links to the high-end links in the global value chain such as cooperative research and development, joint design, marketing and brand cultivation, so as to build a global supply chain system with China’s initiative, complementary advantages and mutual benefit. The third is to promote the construction of border economic cooperation zones, cross-border economic cooperation zones and overseas economic and trade cooperation zones along the "Belt and Road", encourage enterprises to set up overseas distribution and service networks, logistics distribution centers, overseas warehouses, etc., establish a supply chain system based on the local market, improve the ability of global supply chain coordination and resource allocation, and create a more globally competitive industrial cluster.

(Author: Institute of Circulation and Consumption, Institute of International Trade and Economic Cooperation, Ministry of Commerce)

"The economy has developed, but the spirit has lost. Can that country be called strong?" On March 18th, 2014, the question raised by General Secretary of the Supreme Leader at the enlarged meeting of the Standing Committee of Lankao County Committee in Henan Province was thought-provoking.

A nation without spiritual strength can hardly strive for self-improvement. The reason why the Chinese nation can be reborn after suffering setbacks is precisely because the national spirit has provided strong support.

In 2016, at the opening ceremony of the 10th National Congress of the China Federation of Literary and Art Circles and the 9th National Congress of the Chinese Writers Association, the General Secretary pointed out that the motherland is the most solid support of the people and the hero is the brightest coordinate of the nation.

Coordinate is an important tool for us to position ourselves and know the world, and it is also our goal direction and spiritual guidance on the road of life.

The general secretary asked for heroes as "coordinates", which conveyed deep-seated culture and values. This is the respect and admiration for heroes, but also the inheritance and promotion of heroic spirit and heroic quality.

In September 2015, during the 26th collective study in the 18th the Political Bureau of the Central Committee, the General Secretary talked about the letters from the martyrs of Zhao Yiman.

He pointed out that the letters from these revolutionary martyrs are the most vivid and convincing teaching materials for the education of ideals and beliefs, and they should be compiled into volumes and distributed to party member and cadres, and everyone should read and think about them frequently.

In September 2018, during an inspection tour in Fushun, Liaoning Province, the General Secretary went to lei feng memorial to visit Lei Feng’s handwriting, relics and photos to learn about his life story.

He emphasized that we should not only learn from the spirit of Lei Feng, but also learn from the practices of Lei Feng, turn lofty ideals, beliefs and moral pursuit into concrete actions, embody them in ordinary work and life, make our due contribution, and pass on the spirit of Lei Feng from generation to generation.

In August 2020, the general secretary came to Luojiatuan section of Chaohu levee in Hefei, Anhui. When visiting the relatives of comrades who died unfortunately in flood control and flood fighting, the general secretary said: "Your relatives are also our relatives, relatives of the people of the motherland, and heroes in our minds. When the Chinese nation is in danger, there are always some heroes who come forward. This is the embodiment of the great Chinese national spirit, and we will all respect them. "

… … … …

Different times make different heroes.

From ancient times to the present, whether it is Yue Fei’s loyal service to the country, Lin Zexu’s Destruction of Opium at Humen, or Huang Jiguang’s sacrifice to block the loophole, Wang Jinxi’s use of his body to mix cement and suppress the blowout … … They all stood up the backbone of the nation with their firm beliefs and feats of brave sacrifice and selfless dedication. They are all the shining coordinates of the national spirit.

Any country, any nation, at any time, needs its own hero.

Today, we also need heroes.

Poverty alleviation, fighting the epidemic, fighting the flood, and fighting the fire … … In the new era, ordinary people who stand up at critical moments and have the courage to take the lead and get out at critical moments have jointly built a monument to heroic spirit.

Qian Qihu, an expert in protective engineering who casts shields for the country, said: "When the motherland needs it, we will respond to the call"; Nie Haisheng, an astronaut who is determined to serve the country, said: "Be ready at all times and accept the choice of the motherland"; Du Fuguo, a demining soldier loyal to his mission, said, "Stand back and let me do it" … …

As the general secretary said, all people who control their own destiny for the Chinese nation and create a new path for national development are national heroes and national glory.

Love heroes and cherish heroes, and the country can produce heroes in large numbers; Only when heroes come forth in large numbers can the nation truly rise and the country truly become strong.

Since the 18th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader has always led the whole society to admire, defend and learn from heroes, praised meritorious figures with lofty courtesy, and cared for heroic models with practical actions.

China not only legally stipulates September 30th as the Martyrs’ Memorial Day, and promulgated the Law on the Protection of Heroes and Martyrs in People’s Republic of China (PRC), but also established the honorary commendation system for China’s special meritorious service such as the Medal of the Republic, the Medal of July 1st and the Medal of August 1st. Tell heroic stories, carry forward heroic morality, and convey the distinct value orientation of defending heroic martyrs.

Heroes are the brightest coordinates of the nation.

Taking the hero as the coordinate means that we should consciously integrate the heroic spirit into the practical actions to promote social development and national progress. Only in this way can we stand firm in the torrent of history and stand firm; In order to find a way out in the predicament, go forward bravely!

Kimi Weibo was vomited by netizens

　 　 1905 movie network news There was a major explosion in the coastal area of Tianjin last night, and many stars prayed in Weibo. At noon today, actor Kimi also sent Weibo to pray for Tianjin, calling for help to find out the families of firefighters to tide over the difficulties. However, he used words such as "human flesh" and "self-destruction", and his language was confusing, which was madly vomited by netizens.

　 　 The original text of Weibo, Kimi is as follows:

　 　 It’s not that moths still throw themselves into the fire, only for Tianjin, developed networks, omnipotent meager, please invite people to kill those heroes, remember their appearance, help their families, and share the current difficulties. Because everything will be fine.

　 　 In this regard, netizens did not buy it, and they vomited their "no culture" and "low emotional intelligence" and asked him "Can heroes be eaten by human flesh?" . In the face of netizens’ spit, Kimi then deleted the Weibo.

Special feature of 1905 film network According to the preliminary statistics of the National Film Office, as of November 13th, 2023, the annual box office of China movies exceeded 50 billion yuan, which took 317 days. The domestic movie box office was 41.7 billion yuan, accounting for 83.4%, and the imported movie box office was 8.3 billion yuan, accounting for 16.6%. This is also the total box office of the national movies has returned to 50 billion yuan since the epidemic, which shows that China movies are in a big pattern of recovery and development, steady progress and long-term improvement.

After three years, each schedule reappears its competitiveness.

This year, China’s film market has received many good news.

At the beginning of the Spring Festival, many new films such as the Spring Festival continued to be shown, and finally produced 6.758 billion yuan at the box office of the Spring Festival, ranking second in history, injecting a shot in the arm into the market; On January 31st, 2023, the total box office in China exceeded 10 billion yuan, which also set a new record for the total box office in China film market to break 10 billion yuan at the earliest.

The five-day box office of the "May 1" file (April 29 to May 3) was 1.519 billion yuan, second only to the same period in 2019 and 2021. It is worth mentioning that the long tail effect is strong and it has also entered the top ten of the current box office list. On May 7, 2023, the national box office exceeded 20 billion yuan.

This year’s summer vacation (June 1 to August 31) is even more surprising. China’s film market has ushered in a new breakthrough in box office and movie attendance — — The box office reached 20.619 billion yuan, and the number of people watching movies was 505 million. This is also the first time that the summer file exceeded 20 billion yuan, setting a new box office record. On August 18th, the box office of the national film market in 2023 exceeded 40 billion yuan.

A number of different types of domestic films have been released one after another. With the high quality of their works, the film market continues to be hot, which has triggered a wave of movie-watching craze.

The achievement of "Mid-Autumn National Day" was equally gratifying. Under the impact of the tourism enthusiasm of the first small holiday after the epidemic, it finally ended with a box office score of 2.732 billion.

On November 13th, the annual box office of China movies reached 50 billion yuan. There are still many good films waiting to enter the market, and the total box office in the whole year may exceed 55 billion yuan. This series of data has inspired countless filmmakers.

The quality of the film is excellent, and it is a success.

The box office achievement of 50 billion is inseparable from the continuous release of high-quality films. In 2023, there were 55 films with box office exceeding 100 million, of which 37 were made in China, accounting for more than half.

The top ten films in this year’s box office are all made in China, namely, Man Jiang Hong, Wandering Earth 2, Put All Your Eggs on It, The Disappeared She, The First Part: Worship the Gods, In an Octagonal Cage, Three Wan Li in Chang ‘an, Bears with Me, and Unfamiliar Road in Life. The box office of these ten films all exceeded 1 billion yuan.

What’s more worth mentioning is that this year’s domestic films not only have outstanding box office performance, but also have a breakthrough in word of mouth. According to the survey results of movie audience satisfaction in China, this year’s Spring Festival audience satisfaction score was 87.1 points, up 1.8 points year-on-year; The audience satisfaction score of "May 1st" movies is 83.3, which is also the highest value of survey satisfaction in the same period in recent years. The audience satisfaction score of summer movies was 84.5, and the satisfaction score of six movies exceeded 84, ranking the highest in number and proportion in the same period of the previous year; The satisfaction of five key films in Mid-Autumn Festival and National Day files all exceeded 80 points, and the satisfaction of three films exceeded 83 points.

With the release of a large number of high-quality films and the audience’s enthusiasm for watching movies, we can see the possibility and potential of China film market.

The film industry continues to develop healthily.

This year’s film market is a year of rapid recovery, and the current achievements are gratifying. However, compared with the same period in 2019, the total box office of 50 billion yuan has only recovered to about 85%, and there is still 10%~15% room for improvement. Therefore, it is still necessary to promote the sustainable and healthy development of China’s films in the future, and bring more vitality and possibilities to China’s film market.

Professor Tsinghua University said: Besides relying on several strong schedules, we also need to pay attention to the schedule of every weekend, so the market needs more high-quality movies. We should have more movies for the audience to choose from, so that the audience can not only have the impulse and desire to watch movies on holidays, but also go to the cinema to watch movies on Friday and Saturday, and they can all choose their favorite movies. Sufficient quality film supply is always the first condition for the development and prosperity of the film market.

In addition, it is also an important step to improve the film market in China to speed up the reform of film distribution mode and do a good job in the distribution of different films. Let some fans of minority films also have the opportunity to walk into the cinema to watch movies. Although the relative number of them seems to be a small number, when they are added together, it is also an absolute majority, which is why we advocate separate distribution now.

Among the upcoming films, there are many domestic popular new films waiting to enter the market, which have attracted a lot of attention and expectation from the audience, which also shows that China’s film industry has strong resilience and development potential in the future!

1905 movie network news Directed by Hu Mei, written by Zou Jingzhi, starring Fu Dalong, Ma Yili, Olivia (especially), Ma Jinghan, Yao Anlian, and Jiao Huang, a national first-class actor, the historical masterpiece exploring the origin of Peking Opera for 300 years was officially released nationwide today.The film is a collection of top performers in the industry and powerful opera players. It has been polished for six years, and it explores the ups and downs of "Huiban going to Beijing" 300 years ago by taking advantage of the origin of the quintessence of Peking Opera.

　

After six years of painstaking efforts, Hu Mei teamed up with Zou Jingzhi to recount the legend of secret history.

The script of the film Into Beijing was written by Zou Jingzhi, a famous screenwriter in China, for three years. The story is based on the colorful event of "Huiban going to Beijing" in the history of Peking Opera’s origin 300 years ago. It tells the story of the feud between the Beijing Palace and Quyi Pear Garden, and the seclusion of Yue Jiu, a master of opera, and the rebellion of Wang Runsheng, a popular martial artist, at the end of the Qianlong period of Qing Dynasty, when the emperor wanted to celebrate his eightieth birthday in Beijing.

　

Hu Mei, a famous fifth-generation female director in China, was deeply touched by the spirit of "ocean deep, the drama is bigger than the sky" in the script, and resolutely took over the guide. In order to present the essence of Peking Opera on the screen accurately and to the extreme, Hu Mei personally visited all parts of Anhui Province to explore the survival status of Peking Opera among the people, which was very shocking. "Children who enter school in Lian Gang can sing an authentic Peking Opera anytime and anywhere, which shows the importance of inheritance". After the visit, Hu Mei hoped to use the time of a movie to awaken the young audience’s interest in the art of Peking Opera, which was especially admirable.

Kasi’s strength breaks through the unity of Fu Dalong people and drama, and Ma Yili and Olivia are hard to reconcile.

In the previously exposed trailer of "Entering Beijing", each character’s excellent lines and hidden "divine eye skills" left a very deep impression on the audience.

　

Fu Dalong’s performance, which has always been low-key, is one of the important reasons why many audiences look forward to Entering Beijing. Hu Mei, the "winner of the Triple Crown", plays Yue Jiu, a great master of traditional Chinese opera. You know, this is the first time that Fu Dalong has played a leading role in film and television works. According to director Hu Mei, before the filming, Fu Dalong’s opera skills were close to zero, but he refused to use body double and insisted on going into battle in person in every scene. Therefore, Fu Dalong, with the help of the film drama director Ha Dongxue, practiced hard and sleepless, until he became one with Yue Jiu in appearance and even in psychology, and vividly interpreted the opera realm of "no madness, no survival".

Ma Jinghan, who plays the most opposite role to Fu Dalong, is a well-trained Peking Opera student. This time, he plays Wang Runsheng, a popular martial artist in Chuntai class in the film. From the initial deviant, he later sang the drama "A Thousand Miles to Jingniang" with Yue Jiu on the stage in Beijing, which is a legendary fate.

The performances of Feng Gege and Fang Chunrong’s actors Ma Yili and Olivia, who are deeply involved in Wang Runsheng’s emotional entanglements respectively, are also important points in the film. Feng Gege, played by Ma Yili, has both a mature and steady childe costume and an aristocratic style with gorgeous clothes. Her encounter with Runsheng is like the love of boya in her childhood, and her feelings are hidden.

Fang Chunrong, played by Olivia, once won the screams of many post-90s and even post-00s audiences when the film was screened. Her interpretation of Chunrong reproduces the pure beauty of women in the mountains in detail, and with extremely gentle and charming eyes, it shows the infinite charm of graceful and touching, and teaches Runsheng to treat each other with the warmest feelings. In the film, Fang Chunrong’s time span of nearly 10 years is accurately presented in Olivia’s beautiful, delicate and moving control. She also won her first international film festival trophy — — The Best Supporting Actress Award in the 10th Macau International Film Festival shows its important position in the film.

The emotional entanglement between Chunrong and Gege and Runsheng can be said to be a very heavy plot clue in Entering Beijing. What is the result of this confusing love puzzle, which needs the audience to go to the cinema to reveal it in person.

On the day of release, the film simultaneously exposed the ending song "Who will take care of your beauty" MV, which was sung by Mi Liang, who plays the imperial concubine in the film. The euphemistic singing combined the two musical elements of ancient style and Beijing opera, which made people listen to it and made up for the twists and turns in the film.

　

The roadshow has been reported frequently, and the young audience has recommended it as a domestic platform for good drama.

On May 8th and 9th, "Into the Capital" was shown in several cinemas in Beijing, and the full-house spectacle surprised Hu Mei and Ma Jinghan who attended the post-screening creative exchange meeting.

Surprisingly, most of the praise for movies comes from young audiences who are mainly from the post-90 s and even the post-00 s. In the question-and-answer session of a post-screening communication session, a young movie fan who is only a few years old ran directly to the stage and asked Hu Mei questions. The scene was very interesting and moved other audiences. Hu Mei therefore felt: "Our country now attaches great importance to the education of young people, which is also an important reason why our films can approach young people."

　

At the screening site, many young viewers longed for Hu Mei’s name and specially came to see the true meaning of the new work "Love Bean". Seeing this scene, Ma Jinghan was also "tickled", and immediately opened his mouth with amazement, and performed a classic drama "Dingjun Mountain", which won the applause of the whole hall with his professional opera skills. Not only that, many fans from Ma Yili and Olivia attended the screening.

Original Xu Chao, I’m Chaoski.

After talking about "cauliflower" for so long, the old readers who pay attention to me can be said to be very familiar with it. However, there are still many hin people coming to ask questions about sharp tips every day.

Today, I will tell you enough about condyloma acuminatum once.

Now, if you see friends here, please sit up straight and put down your legs. Let’s begin our little class.

What is condyloma acuminatum?

Condyloma acuminatum, also known as "anal genital warts", usually manifests as soft papules or patches on the external genitalia, perianal skin, perineum or groin.

HPV is a kind of naked double-stranded DNA virus without envelope, belonging to the family Papillomavirus.

At present, among more than 200 subtypes of HPV that have been identified, more than 40 subtypes can spread through sexual contact and infect the anal genital area.

According to the carcinogenicity, HPV is divided into high-risk type and low-risk type. 90%-95% of condyloma acuminatum cases are caused by low-risk HPV types 6 and 11 [1,2].

How is condyloma acuminatum spread?

Human is the only natural reservoir of HPV, and the infected person is the source of HPV infection. There are many HPV in the genital skin mucosa, which is the repository of HPV and the source of virus transmission.

HPV spreads through contact with infected skin or mucosa, and the virus invades epidermal basal cells through tiny scratches. Verruca is not necessary for virus transmission, but it is highly contagious because of its high viral load.

Transmission route

1. Sexual transmission: it is the most important route of transmission, and skin-mucous contact in heterosexual or homosexual sex can cause infection [3].

2. Vertical transmission: It is common for mothers infected with HPV in reproductive tract to transmit it to newborns through placenta and yindao delivery. For example, recurrent papilloma in children’s respiratory tract may be caused by children infected with HPV6/11.

3. Indirect contact transmission: A small number of patients may get sick through non-sexual contact infection. According to some data, 10% of women were infected with HPV before they lived in apricot [4], suggesting that contact between mouth and hands and raw zhi devices can also infect HPV.

HPV infection can enter the incubation period without obvious symptoms and signs. The incubation period is usually 3 weeks to 8 months, with an average of 3 months. Studies have shown that in patients with condyloma acuminatum after new HPV infection, the median time from the detection of HPV6 or HPV11 to the discovery of condyloma acuminatum is 2.9 months [5].

What are the clinical manifestations and symptoms after being infected with condyloma acuminatum?

Appearance and texture: At the initial stage, the lesions of condyloma acuminatum showed local small papules, which gradually increased or increased from the needle to the millet size and spread to the surrounding area. The wart body can be single or multiple, and it can be papillary, cockscomb-shaped, cauliflower-shaped, flat, dome-shaped, filamentous, mushroom-shaped, pedicled, cerebral gyrus-shaped, plaque-like, smooth (especially on penis body) and so on. Condyloma acuminatum is soft to the touch, ranging from 1mm in diameter to several centimeters in size.

Color: Warts vary in color, ranging from pink to crimson (non-keratinizing lesions), gray (severe keratinizing lesions), brown-black (pigmented lesions) and violet.

Location: For boys, condyloma acuminatum mainly occurs in prepuce, Gui head, coronary sulcus, frenulum, Penis, urethral orifice, perianal region and scrotum. Girls are more likely to occur in Labia, urethral orifice, Vagina mouth, perineum, Vagina wall, cervix and perianal region. If anal sex occurs, warts may appear in the perianal region, anal canal and rectum for the recipient. In addition, if oral sex is performed, warts may also appear in the mouth.

Symptoms: There are generally no symptoms after being infected with condyloma acuminatum, which is one of the reasons why many people do not pay attention to or even delay treatment. A few people may have itching, foreign body sensation, pressure or burning sensation. Due to the increase of brittleness of skin lesions and friction, the skin is broken, soaked, eroded, bleeding or secondary infection, resulting in special odor. In addition, female patients may have increased vagina secretion.

Because condyloma acuminatum is easy to recur, or the warts affect daily life, patients often feel shame, social isolation, anxiety, depression, fear and guilt, and they are also worried that condyloma acuminatum will affect future fertility and increase cancer risk.

In addition, condyloma acuminatum also has a great influence on the feelings between sex partner, which may lead to family conflicts and even lead to the breakdown of relationships.

How to diagnose condyloma acuminatum?

Generally speaking, most patients infected with condyloma acuminatum may have contact history, such as multiple sexual partners, high-risk apricot behavior, or sexual partners with infection history, or close indirect contact history with patients with condyloma acuminatum, and so on. Through these medical histories, combined with the typical clinical manifestations of condyloma acuminatum, the diagnosis can be basically made through face-to-face diagnosis.

For those who cannot be clearly diagnosed by face-to-face examination, they can also be diagnosed by auxiliary examination [6].

1. Acetic acid white test: 3%-5% acetic acid solution is wet-applied or coated on the lesion to be examined and the surrounding skin mucosa. Within 3-5 minutes, if you see a uniform whitening area, it is a positive reaction.

2. Dermatoscope: Dermatoscope can non-invasively, quickly and clearly identify skin lesions, hyperplastic blood vessels and structures that cannot be recognized by naked eyes. Many literatures at home and abroad reported that the diagnostic rate of atypical condyloma acuminatum and tiny condyloma acuminatum by dermatoscope was over 90%.

3. Nucleic acid amplification test: HPV in skin lesions was detected by amplifying HPV-specific genes (L1, E6, E7 region genes), and nucleic acid detection methods included polymerase chain reaction (PCR), real-time fluorescence PCR, and in-situ hybridization test with nucleic acid probes.

4. Pathological examination: For typical skin lesions, histopathological biopsy is unnecessary. If there are some conditions such as uncertain diagnosis, pathological examination can be performed.

In addition, for condyloma acuminatum in anus, vagina and urethra, anoscope, colposcope and urethroscope may be needed for auxiliary examination.

How should condyloma acuminatum be treated?

If you are unfortunately infected with condyloma acuminatum, don’t panic, go to the dermatology department of public hospitals as soon as possible, and sometimes go to urology (boys)/gynecology (girls) for treatment.

The purpose of treating condyloma acuminatum is to remove the wart as soon as possible and eliminate the subclinical infection around the wart as much as possible to reduce or prevent recurrence.

Some people found out that the other person had warts after apricot behavior, and asked if they could use blocking drugs. Unfortunately, there are no blocking drugs for HPV (HIV has related blocking drugs).

Not only are there no blocking drugs, but there are no effective antiviral drugs against HPV at present, so it is impossible to eradicate HPV infection by systematic application of antiviral drugs [7].

If you find yourself growing warts, you can use drugs, physics, surgery, chemistry and other methods to remove them. However, at present, there is no definite evidence to show which treatment scheme is superior to other schemes, and no treatment scheme is suitable for all patients and all warts. All treatment methods have a certain recurrence rate.

According to the suggestion of Clinical Diagnosis and Treatment Guidelines for Condyloma Acuminatum in China (2021 Complete Edition), "The treatment of condyloma Acuminatum can be based on the size, number, location and shape of wart, the patient’s wishes, economic conditions and adverse reactions, and fully consider the individual differences of patients’ age, immune status and compliance, etc." [6].

Drug treatment includes: 0.5% podophyllotoxin tincture, 5% imiquimod cream, 80%-90% trichloroacetic acid solution and so on.

Physical therapy includes: cryotherapy, laser therapy, ionization and high frequency electrotome therapy, etc.

If the number of warts is small, pedicled or large, shearing and excision can be used under local anesthesia, supplemented by electrocautery to destroy the residual warts and control bleeding, without suture.

Photodynamic therapy is suitable for removing small warts and basal therapy after physical therapy to remove large warts. It can be used for the treatment in the cavity such as anal canal, urethral orifice, urethra and cervical canal.

Recurrence and cure

After treatment, condyloma acuminatum is cured by the disappearance of wart body.

However, the recurrence rate of condyloma acuminatum is very high, and the recurrence rate reported by different documents varies greatly, ranging from 10% to 70%. The recurrence rate is the highest within 3 months, and it gradually decreases with time.

At present, most scholars believe that if condyloma acuminatum does not recur after 6-9 months of treatment, the chance of recurrence will be reduced.

Although the recurrence rate of condyloma acuminatum is high, don’t think that you have a "terminal disease" after infection, but have confidence in the treatment.

How to prevent condyloma acuminatum?

Want to prevent condyloma acuminatum, in fact, it is not difficult, four words: "totally".

For people who have no apricot life, there is basically no need to worry about whether they will be infected with condyloma acuminatum. You know, avoiding apricot life is the most reliable way to prevent genital HPV infection.

If you want to have apricot behaviors, don’t engage in unsafe and high-risk apricot behaviors, such as making fire contracts and commercial apricot behaviors. Limiting the number of sex partner can reduce the risk of condyloma acuminatum.

In addition, wearing condoms in apricot life can also prevent condyloma acuminatum to some extent. However, wearing a condom may not be able to protect you, because you may also be infected with HPV in places that are not covered by condoms [8]. Don’t think it’s really safe to wear a condom when unsafe apricot behavior occurs. The safest thing is to avoid high-risk apricot behavior.

Vaccination with HPV vaccine can also prevent HPV infection, and tetravalent or nonavalent HPV vaccine can prevent 90%-95% of condyloma acuminatum. However, if you have been infected with HPV or have grown condyloma acuminatum, it is useless to vaccinate.

I’ve talked so much, I don’t know if you can read it carefully. Mainly because I have received too many inquiries about condyloma acuminatum, I sincerely hope that everyone can protect themselves and others and be healthy.

It’s not easy to write. Don’t you give a "like" or "watching" when you pass by?

references

[1] GARLAND S M, STEBEN M, SINGS H L, et al. Natural history of genital warts: analysis of the placebo arm of 2 randomized phase III trials of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine [J]. J Infect Dis, 2009, 199(6): 805-14.

[2] BALL S L, WINDER D M, VAUGHAN K, et al. Analyses of human papillomavirus genotypes and viral loads in anogenital warts [J]. J Med Virol, 2011, 83(8): 1345-50.

[3] WRIGHT T C, JR. Natural history of HPV infections [J]. J Fam Pract, 2009, 58(9 Suppl HPV): S3-7.

[4] TAY S K, HO T H, LIM-TAN S K. Is genital human papillomavirus infection always sexually transmitted? [J]. Aust N Z J Obstet Gynaecol, 1990, 30(3): 240-2.

[5] WINER R L, KIVIAT N B, HUGHES J P, et al. Development and duration of human papillomavirus lesions, after initial infection [J]. J Infect Dis, 2005, 191(5): 731-8.

Dermatology and Venereology Branch of Chinese Medical Association, Dermatologist Branch of Chinese Medical Association, Dermatology and Venereology Committee of Chinese Rehabilitation Medical Association. Clinical diagnosis and treatment guidelines for condyloma acuminatum in China (2021 full edition) [J]. chinese journal of dermatovenereology, 2021, 35(4): 359-74.

[7] WORKOWSKI K A, BOLAN G A, CENTERS FOR DISEASE C, et al. Sexually transmitted diseases treatment guidelines, 2015 [J]. MMWR Recomm Rep, 2015, 64(RR-03): 1-137.

[8] GILSON R, NUGENT D, WERNER R N, et al. 2019 IUSTI-Europe guideline for the management of anogenital warts [J]. J Eur Acad Dermatol Venereol, 2020, 34(8): 1644-53.

Disclaimer: Some pictures are from the Internet. If there is any infringement, please contact to delete them.

-End of this period-

Read the original text

　　Shanghai, June 4th (Reporter Jiang Hongbing) The tetravalent recombinant norovirus vaccine developed by Shanghai Pasteur Institute of China Academy of Sciences has been approved by National Medical Products Administration recently, and has officially entered clinical research as a national class I preventive biological product.

　　Norovirus is the number one pathogen of acute viral gastroenteritis. How to develop a vaccine with broad protection has been an international problem for decades. Huang Zhong, a researcher from Shanghai Pasteur Institute, led the research team to construct a multivalent recombinant Norovirus vaccine prototype based on virus-like particles (VLP) by using genetic engineering technology. In April 2015, the Institute signed a cooperation agreement with Zhifei Bio to jointly develop a multivalent norovirus vaccine. The two sides worked together to tackle key problems, and it took four years to complete the pre-clinical research and development and clinical trial application of tetravalent recombinant norovirus vaccine (Pichia pastoris), and now it has been approved to carry out clinical trials. The vaccine contains recombinant virus-like particle antigens of four major Norovirus epidemic genotypes, which can theoretically prevent 80%— 90% norovirus infection and acute gastroenteritis caused by norovirus are the multivalent norovirus vaccine with the second highest clinical license price in the world.

Special feature of 1905 film network Insight into the film industry and embrace China films. In 2023, China Film Report "Blue Feather Living Room" launched the "Dialogue Spring" specially planned by the two sessions, inviting representatives from ten film companies to jointly make a beautiful vision of China’s films moving forward in the wind. From welcoming spring to entering spring. Now, once again, starting from the booming Spring Festival, we are working hand in hand with filmmakers to dream of 2024, when China movies are surging.

The latest "China Film Report" and "Blue Feather Meeting Room" special program of the two sessions — — "Dialogue Spring", the first phase welcomes "Head of China Film", member Chinese People’s Political Consultative Conference, Party Secretary and Chairman of China Film Group, and Chairman and General Manager of China Film Co., Ltd. Looking back at the eye-catching transcripts handed over in the past year, and looking forward to the next heavy new films that will be dedicated to the audience, China Film will continue to lead and promote the sustained and high-quality development of China’s film industry by deepening its content and exploring technology.

China film continues to deepen the content layout market.

Exposure trends of heavy new films such as "Volunteer 2"

In the past Spring Festival, China Film participated in the production and distribution of many films. The record-breaking data and the booming momentum made Fu Ruoqing feel the unity of the whole industry and the confidence brought by the return of the audience.

"The Spring Festival file has achieved such results. First, there is supply. The number and types of films supplied this year are very rich. Second, I think it is the audience’s return to the cinema, which has given the greatest support to this Spring Festival file, showing a decline in ticket prices and an increase in the number of people watching movies." Fu Ruoqing bluntly said that this is what the industry most wants to see: "It marks the cultural and entertainment life of movies as the masses, and more people are willing to participate."

In 2023, China Film’s business performance in the industry was also very eye-catching, with 37 films produced and released, and 570 films led or indirectly participated in the distribution.

The completion of these market layouts relies on the continuous deepening of China Film: "In the past three years, we have accumulated a large number of creative scripts and films to be completed at the shooting level, so once there is such a stage in the market, we can come up with corresponding works to show." Fu Ruoqing also said that in the process of creation and production, various production units have really "twisted into a rope".

Looking forward to 2024, the new film list that China Film will present to the audience is also full of gold and sincerity. On the basis of the first part, "Volunteer Army: Attack of Heroes 2" further enhances the story of the characters and expresses the feelings and dedication of "small family" and "everyone". In order to welcome the 75th anniversary of the founding of New China, China Film also plans to bring this blockbuster sequel to the National Day this year, and the later stage of the film has been basically completed.

Another work that has attracted much attention is The Legend of the Condor Heroes: The Great Man, which has been put into elaborate post-production after the filming. 2024 coincides with the centenary of birth, and China Film also hopes to dedicate this classic adaptation to martial arts culture lovers and fans at the most appropriate time.

Fu Ruoqing said that from the script stage to the later stage, every time I went to the film crew to visit the class, then to the sample film and the final editing, everyone was satisfied with this "Legend of the Condor Heroes". From the director’s unconstrained creation to the new batch of actors trained, it will definitely surprise the audience: "The costumes are very good, and their interpretation can also make everyone shine."

In addition, at present, China Film is still working hard to create a film reflecting the life of Macao people and celebrate the 25th anniversary of Macao’s return to China: "We plan to start filming in April and strive to release it at the time of Macao’s return at the end of the year, so that everyone can see what changes one country, two systems has brought to Macao after the return."

Explore the upgrading of technology and production capacity and pay close attention to social phenomena.

China Film actively promotes the high-quality development of China films.

Not only deeply cultivate the content, but also China Film has been actively exploring the upgrading of film technology and promoting the improvement of film production capacity. Take CINITY, the core projection technology, as an example. Since its birth, this projection mode has entered the fourth generation stage: "Last year, we launched CINITY, the first version of 4K120 LED. It changed the traditional projection mode and adopted the self-luminous mode, and there was no projection room. " Next, what kind of revolution will the change of projection mode bring to the industry? Fu Ruoqing thinks this is full of great daydream space.

Various technologies are also feeding back and helping creation. Another blockbuster new work of China Film in 2024, "Only Green", adopted CINITY high frame rate camera: "The purpose is to hope that every scene and every movement can express more delicately and accurately what these dancers have done to interpret the roles. The sound and immersion effects of the theater also make his viewing impact stronger. "

In addition, upcoming films will also be shown in cinemas in CINITY high format. This has further promoted the goal of China Film to "go out and bring in" and actively promote the cultural exchange between Chinese and foreign films from the technical level. The introduction of overseas films helps the audience to better understand different cultures and appreciate world masterpieces, and also helps filmmakers to better understand the development trend of the industry and improve their industrialization and narrative expression.

At this year’s National People’s Congress, Fu Ruoqing also made two proposals to pay close attention to social phenomena from the perspective of the film industry. One is that in recent years, criminals have used film investment to commit fraud. I hope to form more channels and platforms, so that investors should not be deceived and fooled; Another proposal is related to the creation of the film "Genius Translator". Through the film, we can understand the plight of patients with two-way mental disorders. Fu Ruoqing expects to help everyone form a cognition through the film and truly enhance people’s family well-being.

"The high quality of the film is nothing more than two points. The first is the content, and the second is the technical level. Content, to create more films accepted by the market and loved by the audience, technology should rely on all aspects of China industry, China economy and China society to promote the film industry. " Fu Ruoqing believes that with such a foundation, China films will surely have a bright future of high-quality development.