Inheriting the red gene and continuing the red vein Henan strengthens the protection of revolutionary cultural relics to do so.

  In order to give full play to the important role of revolutionary cultural relics in carrying forward the revolutionary tradition and culture, strengthening the construction of socialist spiritual civilization, and promoting the integration strategy of cultural tourism and cultural innovation, Henan recently issued the Notice on Further Strengthening the Protection, Management and Utilization of Revolutionary Cultural Relics in the New Era.

  Henan is rich in revolutionary cultural relics, involving more than 2,500 revolutionary cultural relics protection units.

  It is understood that there are more than 2,500 revolutionary cultural relics protection units (more than 4,000 points) in Henan Province; It has been recognized that two batches of revolutionary cultural relics have been published, including 366 immovable revolutionary cultural relics and 7756 movable precious cultural relics (sets); There are 151 memorial halls of revolutionary museums managed by various departments at all levels.

  Publicity Department of the Communist Party of China, Ministry of Culture, Tourism, Ministry of Finance and National Cultural Heritage Administration have divided Henan into six revolutionary cultural relics protection and utilization areas, including Hubei-Henan-Anhui area, Shanxi-Hebei-Henan area, Long March (Red 25th Army) area, Hebei-Shandong-Henan area and Huaibei area, involving 17 provincial cities and 87 counties (cities).

  The "Notice" adheres to the working principle of "protection first, strengthening management, tapping value, effectively utilizing and making cultural relics alive", pays attention to key points, supplements shortcomings and strong and weak items, further improves the protection status of revolutionary cultural relics in the province, gives full play to the advantages of revolutionary cultural relics resources, and improves the level of exhibition and utilization of revolutionary cultural relics. So as to comprehensively enhance the inheritance ability of protection and management, form a distinctive and nationally influential inheritance system for the protection and utilization of revolutionary cultural relics, better inherit the red genes, continue the red veins, and enhance spiritual strength.

  Strengthen the protection of revolutionary cultural relics and deepen the research and interpretation of revolutionary cultural relics

  The "Notice" recognizes the publication of the revolutionary cultural relics list in Henan Province, strengthens the protection of revolutionary cultural relics in the collection, and implements the maintenance and protection of revolutionary sites. Promote the protection and utilization of revolutionary cultural relics, and promote the pilot work of the protection and utilization of low-level immovable revolutionary cultural relics. Adhere to both rescue protection and preventive protection, and comprehensively enhance the ability to protect revolutionary cultural relics.

  At the same time, it is pointed out that it is necessary to build a collaborative research base for revolutionary cultural relics by relying on colleges and universities and memorial halls of revolutionary museums. We will promote the rescue, collection and research of historical materials of revolutionary cultural relics in an orderly manner, and deeply explore and expound the ideological connotation, time value, historical significance and educational significance of revolutionary cultural relics.

  Expand the utilization mode of revolutionary cultural relics, improve the exhibition level and educational function

  The "Notice" calls for strengthening the classified and rational utilization of revolutionary sites, improving the opening level of revolutionary sites, and further exerting comprehensive service functions. Use market mechanism to develop more cultural and creative products and promote cultural consumption. Promote the integration of red tourism with rural tourism, eco-tourism and other formats, and help rural revitalization and the revitalization and development of old revolutionary areas.

  In order to better promote the construction of revolutionary museums in Henan, the province supports qualified revolutionary museums to be upgraded to national first, second and third grade museums. Around major historical events and important time nodes, we will plan and promote a number of revolutionary cultural relics exhibitions with distinctive themes, profound connotations, novel forms and online and offline integration. Encourage innovative ways to spread revolutionary cultural relics, make rational use of modern scientific and technological means, enhance the expressive force, communication power and influence of revolutionary cultural relics exhibitions, and vividly spread red culture.

  At the same time, we should make full use of revolutionary cultural relics resources, take the initiative to serve the "four histories" study and education, and support the education department to use revolutionary cultural relics resources to carry out ideological and political work in schools. Support the construction of the national red gene inheritance platform and enrich the content of cyberspace revolutionary culture. Organize the training of red commentators and build a team of revolutionary spirit communication talents.

  In order to better promote the protection work, Henan will establish a coordination mechanism for revolutionary cultural relics, study and solve major problems in the management and utilization of revolutionary cultural relics, and strengthen supervision and inspection. Increase financial input, actively implement the spirit of the reform of the division of financial powers and expenditure responsibilities between provinces, cities and counties in the field of public culture, and further improve the financial guarantee mechanism for the protection of revolutionary cultural relics. We will improve laws and policies, promote the introduction of local laws and regulations on the protection of life and cultural relics at the provincial level, and encourage all localities to formulate local laws and regulations on the protection of revolutionary cultural relics in light of actual conditions. (Reporter Mo Yuhua)

In 2023, the total box office of China movies broke 50 billion! How many movies did you watch this year?


Special feature of 1905 film network According to the preliminary statistics of the National Film Office, as of November 13th, 2023, the annual box office of China movies exceeded 50 billion yuan, which took 317 days. The domestic movie box office was 41.7 billion yuan, accounting for 83.4%, and the imported movie box office was 8.3 billion yuan, accounting for 16.6%. This is also the total box office of the national movies has returned to 50 billion yuan since the epidemic, which shows that China movies are in a big pattern of recovery and development, steady progress and long-term improvement.



After three years, each schedule reappears its competitiveness.


This year, China’s film market has received many good news.


At the beginning of the Spring Festival, many new films such as the Spring Festival continued to be shown, and finally produced 6.758 billion yuan at the box office of the Spring Festival, ranking second in history, injecting a shot in the arm into the market; On January 31st, 2023, the total box office in China exceeded 10 billion yuan, which also set a new record for the total box office in China film market to break 10 billion yuan at the earliest.



The five-day box office of the "May 1" file (April 29 to May 3) was 1.519 billion yuan, second only to the same period in 2019 and 2021. It is worth mentioning that the long tail effect is strong and it has also entered the top ten of the current box office list. On May 7, 2023, the national box office exceeded 20 billion yuan.



This year’s summer vacation (June 1 to August 31) is even more surprising. China’s film market has ushered in a new breakthrough in box office and movie attendance — — The box office reached 20.619 billion yuan, and the number of people watching movies was 505 million. This is also the first time that the summer file exceeded 20 billion yuan, setting a new box office record. On August 18th, the box office of the national film market in 2023 exceeded 40 billion yuan.


A number of different types of domestic films have been released one after another. With the high quality of their works, the film market continues to be hot, which has triggered a wave of movie-watching craze.



The achievement of "Mid-Autumn National Day" was equally gratifying. Under the impact of the tourism enthusiasm of the first small holiday after the epidemic, it finally ended with a box office score of 2.732 billion.


On November 13th, the annual box office of China movies reached 50 billion yuan. There are still many good films waiting to enter the market, and the total box office in the whole year may exceed 55 billion yuan. This series of data has inspired countless filmmakers.


The quality of the film is excellent, and it is a success.


The box office achievement of 50 billion is inseparable from the continuous release of high-quality films. In 2023, there were 55 films with box office exceeding 100 million, of which 37 were made in China, accounting for more than half.


The top ten films in this year’s box office are all made in China, namely, Man Jiang Hong, Wandering Earth 2, Put All Your Eggs on It, The Disappeared She, The First Part: Worship the Gods, In an Octagonal Cage, Three Wan Li in Chang ‘an, Bears with Me, and Unfamiliar Road in Life. The box office of these ten films all exceeded 1 billion yuan.


What’s more worth mentioning is that this year’s domestic films not only have outstanding box office performance, but also have a breakthrough in word of mouth. According to the survey results of movie audience satisfaction in China, this year’s Spring Festival audience satisfaction score was 87.1 points, up 1.8 points year-on-year; The audience satisfaction score of "May 1st" movies is 83.3, which is also the highest value of survey satisfaction in the same period in recent years. The audience satisfaction score of summer movies was 84.5, and the satisfaction score of six movies exceeded 84, ranking the highest in number and proportion in the same period of the previous year; The satisfaction of five key films in Mid-Autumn Festival and National Day files all exceeded 80 points, and the satisfaction of three films exceeded 83 points.



With the release of a large number of high-quality films and the audience’s enthusiasm for watching movies, we can see the possibility and potential of China film market.


The film industry continues to develop healthily.


This year’s film market is a year of rapid recovery, and the current achievements are gratifying. However, compared with the same period in 2019, the total box office of 50 billion yuan has only recovered to about 85%, and there is still 10%~15% room for improvement. Therefore, it is still necessary to promote the sustainable and healthy development of China’s films in the future, and bring more vitality and possibilities to China’s film market.


Professor Tsinghua University said: Besides relying on several strong schedules, we also need to pay attention to the schedule of every weekend, so the market needs more high-quality movies. We should have more movies for the audience to choose from, so that the audience can not only have the impulse and desire to watch movies on holidays, but also go to the cinema to watch movies on Friday and Saturday, and they can all choose their favorite movies. Sufficient quality film supply is always the first condition for the development and prosperity of the film market.



In addition, it is also an important step to improve the film market in China to speed up the reform of film distribution mode and do a good job in the distribution of different films. Let some fans of minority films also have the opportunity to walk into the cinema to watch movies. Although the relative number of them seems to be a small number, when they are added together, it is also an absolute majority, which is why we advocate separate distribution now.



Among the upcoming films, there are many domestic popular new films waiting to enter the market, which have attracted a lot of attention and expectation from the audience, which also shows that China’s film industry has strong resilience and development potential in the future!


Hu Mei’s new work "Into the Capital" was released in Olivia, Ma Yili.


1905 movie network news Directed by Hu Mei, written by Zou Jingzhi, starring Fu Dalong, Ma Yili, Olivia (especially), Ma Jinghan, Yao Anlian, and Jiao Huang, a national first-class actor, the historical masterpiece exploring the origin of Peking Opera for 300 years was officially released nationwide today.The film is a collection of top performers in the industry and powerful opera players. It has been polished for six years, and it explores the ups and downs of "Huiban going to Beijing" 300 years ago by taking advantage of the origin of the quintessence of Peking Opera.


 

After six years of painstaking efforts, Hu Mei teamed up with Zou Jingzhi to recount the legend of secret history.

The script of the film Into Beijing was written by Zou Jingzhi, a famous screenwriter in China, for three years. The story is based on the colorful event of "Huiban going to Beijing" in the history of Peking Opera’s origin 300 years ago. It tells the story of the feud between the Beijing Palace and Quyi Pear Garden, and the seclusion of Yue Jiu, a master of opera, and the rebellion of Wang Runsheng, a popular martial artist, at the end of the Qianlong period of Qing Dynasty, when the emperor wanted to celebrate his eightieth birthday in Beijing.

 

Hu Mei, a famous fifth-generation female director in China, was deeply touched by the spirit of "ocean deep, the drama is bigger than the sky" in the script, and resolutely took over the guide. In order to present the essence of Peking Opera on the screen accurately and to the extreme, Hu Mei personally visited all parts of Anhui Province to explore the survival status of Peking Opera among the people, which was very shocking. "Children who enter school in Lian Gang can sing an authentic Peking Opera anytime and anywhere, which shows the importance of inheritance". After the visit, Hu Mei hoped to use the time of a movie to awaken the young audience’s interest in the art of Peking Opera, which was especially admirable.


Kasi’s strength breaks through the unity of Fu Dalong people and drama, and Ma Yili and Olivia are hard to reconcile.

In the previously exposed trailer of "Entering Beijing", each character’s excellent lines and hidden "divine eye skills" left a very deep impression on the audience.

 

Fu Dalong’s performance, which has always been low-key, is one of the important reasons why many audiences look forward to Entering Beijing. Hu Mei, the "winner of the Triple Crown", plays Yue Jiu, a great master of traditional Chinese opera. You know, this is the first time that Fu Dalong has played a leading role in film and television works. According to director Hu Mei, before the filming, Fu Dalong’s opera skills were close to zero, but he refused to use body double and insisted on going into battle in person in every scene. Therefore, Fu Dalong, with the help of the film drama director Ha Dongxue, practiced hard and sleepless, until he became one with Yue Jiu in appearance and even in psychology, and vividly interpreted the opera realm of "no madness, no survival".

Ma Jinghan, who plays the most opposite role to Fu Dalong, is a well-trained Peking Opera student. This time, he plays Wang Runsheng, a popular martial artist in Chuntai class in the film. From the initial deviant, he later sang the drama "A Thousand Miles to Jingniang" with Yue Jiu on the stage in Beijing, which is a legendary fate.

The performances of Feng Gege and Fang Chunrong’s actors Ma Yili and Olivia, who are deeply involved in Wang Runsheng’s emotional entanglements respectively, are also important points in the film. Feng Gege, played by Ma Yili, has both a mature and steady childe costume and an aristocratic style with gorgeous clothes. Her encounter with Runsheng is like the love of boya in her childhood, and her feelings are hidden.

Fang Chunrong, played by Olivia, once won the screams of many post-90s and even post-00s audiences when the film was screened. Her interpretation of Chunrong reproduces the pure beauty of women in the mountains in detail, and with extremely gentle and charming eyes, it shows the infinite charm of graceful and touching, and teaches Runsheng to treat each other with the warmest feelings. In the film, Fang Chunrong’s time span of nearly 10 years is accurately presented in Olivia’s beautiful, delicate and moving control. She also won her first international film festival trophy — — The Best Supporting Actress Award in the 10th Macau International Film Festival shows its important position in the film.

The emotional entanglement between Chunrong and Gege and Runsheng can be said to be a very heavy plot clue in Entering Beijing. What is the result of this confusing love puzzle, which needs the audience to go to the cinema to reveal it in person.

On the day of release, the film simultaneously exposed the ending song "Who will take care of your beauty" MV, which was sung by Mi Liang, who plays the imperial concubine in the film. The euphemistic singing combined the two musical elements of ancient style and Beijing opera, which made people listen to it and made up for the twists and turns in the film.

 

The roadshow has been reported frequently, and the young audience has recommended it as a domestic platform for good drama.

On May 8th and 9th, "Into the Capital" was shown in several cinemas in Beijing, and the full-house spectacle surprised Hu Mei and Ma Jinghan who attended the post-screening creative exchange meeting.

Surprisingly, most of the praise for movies comes from young audiences who are mainly from the post-90 s and even the post-00 s. In the question-and-answer session of a post-screening communication session, a young movie fan who is only a few years old ran directly to the stage and asked Hu Mei questions. The scene was very interesting and moved other audiences. Hu Mei therefore felt: "Our country now attaches great importance to the education of young people, which is also an important reason why our films can approach young people."

 

At the screening site, many young viewers longed for Hu Mei’s name and specially came to see the true meaning of the new work "Love Bean". Seeing this scene, Ma Jinghan was also "tickled", and immediately opened his mouth with amazement, and performed a classic drama "Dingjun Mountain", which won the applause of the whole hall with his professional opera skills. Not only that, many fans from Ma Yili and Olivia attended the screening.


How does HPV spread?

Original Xu Chao, I’m Chaoski.

After talking about "cauliflower" for so long, the old readers who pay attention to me can be said to be very familiar with it. However, there are still many hin people coming to ask questions about sharp tips every day.

Today, I will tell you enough about condyloma acuminatum once.

Now, if you see friends here, please sit up straight and put down your legs. Let’s begin our little class.

What is condyloma acuminatum?

Condyloma acuminatum, also known as "anal genital warts", usually manifests as soft papules or patches on the external genitalia, perianal skin, perineum or groin.

HPV is a kind of naked double-stranded DNA virus without envelope, belonging to the family Papillomavirus.

At present, among more than 200 subtypes of HPV that have been identified, more than 40 subtypes can spread through sexual contact and infect the anal genital area.

According to the carcinogenicity, HPV is divided into high-risk type and low-risk type. 90%-95% of condyloma acuminatum cases are caused by low-risk HPV types 6 and 11 [1,2].

How is condyloma acuminatum spread?

Human is the only natural reservoir of HPV, and the infected person is the source of HPV infection. There are many HPV in the genital skin mucosa, which is the repository of HPV and the source of virus transmission.

HPV spreads through contact with infected skin or mucosa, and the virus invades epidermal basal cells through tiny scratches. Verruca is not necessary for virus transmission, but it is highly contagious because of its high viral load.

Transmission route

1. Sexual transmission: it is the most important route of transmission, and skin-mucous contact in heterosexual or homosexual sex can cause infection [3].

2. Vertical transmission: It is common for mothers infected with HPV in reproductive tract to transmit it to newborns through placenta and yindao delivery. For example, recurrent papilloma in children’s respiratory tract may be caused by children infected with HPV6/11.

3. Indirect contact transmission: A small number of patients may get sick through non-sexual contact infection. According to some data, 10% of women were infected with HPV before they lived in apricot [4], suggesting that contact between mouth and hands and raw zhi devices can also infect HPV.

HPV infection can enter the incubation period without obvious symptoms and signs. The incubation period is usually 3 weeks to 8 months, with an average of 3 months. Studies have shown that in patients with condyloma acuminatum after new HPV infection, the median time from the detection of HPV6 or HPV11 to the discovery of condyloma acuminatum is 2.9 months [5].

What are the clinical manifestations and symptoms after being infected with condyloma acuminatum?

Appearance and texture: At the initial stage, the lesions of condyloma acuminatum showed local small papules, which gradually increased or increased from the needle to the millet size and spread to the surrounding area. The wart body can be single or multiple, and it can be papillary, cockscomb-shaped, cauliflower-shaped, flat, dome-shaped, filamentous, mushroom-shaped, pedicled, cerebral gyrus-shaped, plaque-like, smooth (especially on penis body) and so on. Condyloma acuminatum is soft to the touch, ranging from 1mm in diameter to several centimeters in size.

Color: Warts vary in color, ranging from pink to crimson (non-keratinizing lesions), gray (severe keratinizing lesions), brown-black (pigmented lesions) and violet.

Location: For boys, condyloma acuminatum mainly occurs in prepuce, Gui head, coronary sulcus, frenulum, Penis, urethral orifice, perianal region and scrotum. Girls are more likely to occur in Labia, urethral orifice, Vagina mouth, perineum, Vagina wall, cervix and perianal region. If anal sex occurs, warts may appear in the perianal region, anal canal and rectum for the recipient. In addition, if oral sex is performed, warts may also appear in the mouth.

Symptoms: There are generally no symptoms after being infected with condyloma acuminatum, which is one of the reasons why many people do not pay attention to or even delay treatment. A few people may have itching, foreign body sensation, pressure or burning sensation. Due to the increase of brittleness of skin lesions and friction, the skin is broken, soaked, eroded, bleeding or secondary infection, resulting in special odor. In addition, female patients may have increased vagina secretion.

Because condyloma acuminatum is easy to recur, or the warts affect daily life, patients often feel shame, social isolation, anxiety, depression, fear and guilt, and they are also worried that condyloma acuminatum will affect future fertility and increase cancer risk.

In addition, condyloma acuminatum also has a great influence on the feelings between sex partner, which may lead to family conflicts and even lead to the breakdown of relationships.

How to diagnose condyloma acuminatum?

Generally speaking, most patients infected with condyloma acuminatum may have contact history, such as multiple sexual partners, high-risk apricot behavior, or sexual partners with infection history, or close indirect contact history with patients with condyloma acuminatum, and so on. Through these medical histories, combined with the typical clinical manifestations of condyloma acuminatum, the diagnosis can be basically made through face-to-face diagnosis.

For those who cannot be clearly diagnosed by face-to-face examination, they can also be diagnosed by auxiliary examination [6].

1. Acetic acid white test: 3%-5% acetic acid solution is wet-applied or coated on the lesion to be examined and the surrounding skin mucosa. Within 3-5 minutes, if you see a uniform whitening area, it is a positive reaction.

2. Dermatoscope: Dermatoscope can non-invasively, quickly and clearly identify skin lesions, hyperplastic blood vessels and structures that cannot be recognized by naked eyes. Many literatures at home and abroad reported that the diagnostic rate of atypical condyloma acuminatum and tiny condyloma acuminatum by dermatoscope was over 90%.

3. Nucleic acid amplification test: HPV in skin lesions was detected by amplifying HPV-specific genes (L1, E6, E7 region genes), and nucleic acid detection methods included polymerase chain reaction (PCR), real-time fluorescence PCR, and in-situ hybridization test with nucleic acid probes.

4. Pathological examination: For typical skin lesions, histopathological biopsy is unnecessary. If there are some conditions such as uncertain diagnosis, pathological examination can be performed.

In addition, for condyloma acuminatum in anus, vagina and urethra, anoscope, colposcope and urethroscope may be needed for auxiliary examination.

How should condyloma acuminatum be treated?

If you are unfortunately infected with condyloma acuminatum, don’t panic, go to the dermatology department of public hospitals as soon as possible, and sometimes go to urology (boys)/gynecology (girls) for treatment.

The purpose of treating condyloma acuminatum is to remove the wart as soon as possible and eliminate the subclinical infection around the wart as much as possible to reduce or prevent recurrence.

Some people found out that the other person had warts after apricot behavior, and asked if they could use blocking drugs. Unfortunately, there are no blocking drugs for HPV (HIV has related blocking drugs).

Not only are there no blocking drugs, but there are no effective antiviral drugs against HPV at present, so it is impossible to eradicate HPV infection by systematic application of antiviral drugs [7].

If you find yourself growing warts, you can use drugs, physics, surgery, chemistry and other methods to remove them. However, at present, there is no definite evidence to show which treatment scheme is superior to other schemes, and no treatment scheme is suitable for all patients and all warts. All treatment methods have a certain recurrence rate.

According to the suggestion of Clinical Diagnosis and Treatment Guidelines for Condyloma Acuminatum in China (2021 Complete Edition), "The treatment of condyloma Acuminatum can be based on the size, number, location and shape of wart, the patient’s wishes, economic conditions and adverse reactions, and fully consider the individual differences of patients’ age, immune status and compliance, etc." [6].

Drug treatment includes: 0.5% podophyllotoxin tincture, 5% imiquimod cream, 80%-90% trichloroacetic acid solution and so on.

Physical therapy includes: cryotherapy, laser therapy, ionization and high frequency electrotome therapy, etc.

If the number of warts is small, pedicled or large, shearing and excision can be used under local anesthesia, supplemented by electrocautery to destroy the residual warts and control bleeding, without suture.

Photodynamic therapy is suitable for removing small warts and basal therapy after physical therapy to remove large warts. It can be used for the treatment in the cavity such as anal canal, urethral orifice, urethra and cervical canal.

Recurrence and cure

After treatment, condyloma acuminatum is cured by the disappearance of wart body.

However, the recurrence rate of condyloma acuminatum is very high, and the recurrence rate reported by different documents varies greatly, ranging from 10% to 70%. The recurrence rate is the highest within 3 months, and it gradually decreases with time.

At present, most scholars believe that if condyloma acuminatum does not recur after 6-9 months of treatment, the chance of recurrence will be reduced.

Although the recurrence rate of condyloma acuminatum is high, don’t think that you have a "terminal disease" after infection, but have confidence in the treatment.

How to prevent condyloma acuminatum?

Want to prevent condyloma acuminatum, in fact, it is not difficult, four words: "totally".

For people who have no apricot life, there is basically no need to worry about whether they will be infected with condyloma acuminatum. You know, avoiding apricot life is the most reliable way to prevent genital HPV infection.

If you want to have apricot behaviors, don’t engage in unsafe and high-risk apricot behaviors, such as making fire contracts and commercial apricot behaviors. Limiting the number of sex partner can reduce the risk of condyloma acuminatum.

In addition, wearing condoms in apricot life can also prevent condyloma acuminatum to some extent. However, wearing a condom may not be able to protect you, because you may also be infected with HPV in places that are not covered by condoms [8]. Don’t think it’s really safe to wear a condom when unsafe apricot behavior occurs. The safest thing is to avoid high-risk apricot behavior.

Vaccination with HPV vaccine can also prevent HPV infection, and tetravalent or nonavalent HPV vaccine can prevent 90%-95% of condyloma acuminatum. However, if you have been infected with HPV or have grown condyloma acuminatum, it is useless to vaccinate.

I’ve talked so much, I don’t know if you can read it carefully. Mainly because I have received too many inquiries about condyloma acuminatum, I sincerely hope that everyone can protect themselves and others and be healthy.

It’s not easy to write. Don’t you give a "like" or "watching" when you pass by?

references

[1] GARLAND S M, STEBEN M, SINGS H L, et al. Natural history of genital warts: analysis of the placebo arm of 2 randomized phase III trials of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine [J]. J Infect Dis, 2009, 199(6): 805-14.

[2] BALL S L, WINDER D M, VAUGHAN K, et al. Analyses of human papillomavirus genotypes and viral loads in anogenital warts [J]. J Med Virol, 2011, 83(8): 1345-50.

[3] WRIGHT T C, JR. Natural history of HPV infections [J]. J Fam Pract, 2009, 58(9 Suppl HPV): S3-7.

[4] TAY S K, HO T H, LIM-TAN S K. Is genital human papillomavirus infection always sexually transmitted? [J]. Aust N Z J Obstet Gynaecol, 1990, 30(3): 240-2.

[5] WINER R L, KIVIAT N B, HUGHES J P, et al. Development and duration of human papillomavirus lesions, after initial infection [J]. J Infect Dis, 2005, 191(5): 731-8.

Dermatology and Venereology Branch of Chinese Medical Association, Dermatologist Branch of Chinese Medical Association, Dermatology and Venereology Committee of Chinese Rehabilitation Medical Association. Clinical diagnosis and treatment guidelines for condyloma acuminatum in China (2021 full edition) [J]. chinese journal of dermatovenereology, 2021, 35(4): 359-74.

[7] WORKOWSKI K A, BOLAN G A, CENTERS FOR DISEASE C, et al. Sexually transmitted diseases treatment guidelines, 2015 [J]. MMWR Recomm Rep, 2015, 64(RR-03): 1-137.

[8] GILSON R, NUGENT D, WERNER R N, et al. 2019 IUSTI-Europe guideline for the management of anogenital warts [J]. J Eur Acad Dermatol Venereol, 2020, 34(8): 1644-53.

Disclaimer: Some pictures are from the Internet. If there is any infringement, please contact to delete them.

-End of this period-

Read the original text

Headline correlation

                                                                                   

Good news! Norovirus tetravalent vaccine developed in China has officially entered clinical research.

  Shanghai, June 4th (Reporter Jiang Hongbing) The tetravalent recombinant norovirus vaccine developed by Shanghai Pasteur Institute of China Academy of Sciences has been approved by National Medical Products Administration recently, and has officially entered clinical research as a national class I preventive biological product.

  Norovirus is the number one pathogen of acute viral gastroenteritis. How to develop a vaccine with broad protection has been an international problem for decades. Huang Zhong, a researcher from Shanghai Pasteur Institute, led the research team to construct a multivalent recombinant Norovirus vaccine prototype based on virus-like particles (VLP) by using genetic engineering technology. In April 2015, the Institute signed a cooperation agreement with Zhifei Bio to jointly develop a multivalent norovirus vaccine. The two sides worked together to tackle key problems, and it took four years to complete the pre-clinical research and development and clinical trial application of tetravalent recombinant norovirus vaccine (Pichia pastoris), and now it has been approved to carry out clinical trials. The vaccine contains recombinant virus-like particle antigens of four major Norovirus epidemic genotypes, which can theoretically prevent 80%— 90% norovirus infection and acute gastroenteritis caused by norovirus are the multivalent norovirus vaccine with the second highest clinical license price in the world.

Fu Ruoqing in Lan Yu Dialogue: Promoting the High-quality Development of China Films


Special feature of 1905 film network Insight into the film industry and embrace China films. In 2023, China Film Report "Blue Feather Living Room" launched the "Dialogue Spring" specially planned by the two sessions, inviting representatives from ten film companies to jointly make a beautiful vision of China’s films moving forward in the wind. From welcoming spring to entering spring. Now, once again, starting from the booming Spring Festival, we are working hand in hand with filmmakers to dream of 2024, when China movies are surging.


The latest "China Film Report" and "Blue Feather Meeting Room" special program of the two sessions — — "Dialogue Spring", the first phase welcomes "Head of China Film", member Chinese People’s Political Consultative Conference, Party Secretary and Chairman of China Film Group, and Chairman and General Manager of China Film Co., Ltd. Looking back at the eye-catching transcripts handed over in the past year, and looking forward to the next heavy new films that will be dedicated to the audience, China Film will continue to lead and promote the sustained and high-quality development of China’s film industry by deepening its content and exploring technology.



China film continues to deepen the content layout market.

Exposure trends of heavy new films such as "Volunteer 2"


In the past Spring Festival, China Film participated in the production and distribution of many films. The record-breaking data and the booming momentum made Fu Ruoqing feel the unity of the whole industry and the confidence brought by the return of the audience.


"The Spring Festival file has achieved such results. First, there is supply. The number and types of films supplied this year are very rich. Second, I think it is the audience’s return to the cinema, which has given the greatest support to this Spring Festival file, showing a decline in ticket prices and an increase in the number of people watching movies." Fu Ruoqing bluntly said that this is what the industry most wants to see: "It marks the cultural and entertainment life of movies as the masses, and more people are willing to participate."



In 2023, China Film’s business performance in the industry was also very eye-catching, with 37 films produced and released, and 570 films led or indirectly participated in the distribution.


The completion of these market layouts relies on the continuous deepening of China Film: "In the past three years, we have accumulated a large number of creative scripts and films to be completed at the shooting level, so once there is such a stage in the market, we can come up with corresponding works to show." Fu Ruoqing also said that in the process of creation and production, various production units have really "twisted into a rope".



Looking forward to 2024, the new film list that China Film will present to the audience is also full of gold and sincerity. On the basis of the first part, "Volunteer Army: Attack of Heroes 2" further enhances the story of the characters and expresses the feelings and dedication of "small family" and "everyone". In order to welcome the 75th anniversary of the founding of New China, China Film also plans to bring this blockbuster sequel to the National Day this year, and the later stage of the film has been basically completed.



Another work that has attracted much attention is The Legend of the Condor Heroes: The Great Man, which has been put into elaborate post-production after the filming. 2024 coincides with the centenary of birth, and China Film also hopes to dedicate this classic adaptation to martial arts culture lovers and fans at the most appropriate time.



Fu Ruoqing said that from the script stage to the later stage, every time I went to the film crew to visit the class, then to the sample film and the final editing, everyone was satisfied with this "Legend of the Condor Heroes". From the director’s unconstrained creation to the new batch of actors trained, it will definitely surprise the audience: "The costumes are very good, and their interpretation can also make everyone shine."



In addition, at present, China Film is still working hard to create a film reflecting the life of Macao people and celebrate the 25th anniversary of Macao’s return to China: "We plan to start filming in April and strive to release it at the time of Macao’s return at the end of the year, so that everyone can see what changes one country, two systems has brought to Macao after the return."


Explore the upgrading of technology and production capacity and pay close attention to social phenomena.

China Film actively promotes the high-quality development of China films.


Not only deeply cultivate the content, but also China Film has been actively exploring the upgrading of film technology and promoting the improvement of film production capacity. Take CINITY, the core projection technology, as an example. Since its birth, this projection mode has entered the fourth generation stage: "Last year, we launched CINITY, the first version of 4K120 LED. It changed the traditional projection mode and adopted the self-luminous mode, and there was no projection room. " Next, what kind of revolution will the change of projection mode bring to the industry? Fu Ruoqing thinks this is full of great daydream space.


Various technologies are also feeding back and helping creation. Another blockbuster new work of China Film in 2024, "Only Green", adopted CINITY high frame rate camera: "The purpose is to hope that every scene and every movement can express more delicately and accurately what these dancers have done to interpret the roles. The sound and immersion effects of the theater also make his viewing impact stronger. "



In addition, upcoming films will also be shown in cinemas in CINITY high format. This has further promoted the goal of China Film to "go out and bring in" and actively promote the cultural exchange between Chinese and foreign films from the technical level. The introduction of overseas films helps the audience to better understand different cultures and appreciate world masterpieces, and also helps filmmakers to better understand the development trend of the industry and improve their industrialization and narrative expression.



At this year’s National People’s Congress, Fu Ruoqing also made two proposals to pay close attention to social phenomena from the perspective of the film industry. One is that in recent years, criminals have used film investment to commit fraud. I hope to form more channels and platforms, so that investors should not be deceived and fooled; Another proposal is related to the creation of the film "Genius Translator". Through the film, we can understand the plight of patients with two-way mental disorders. Fu Ruoqing expects to help everyone form a cognition through the film and truly enhance people’s family well-being.


"The high quality of the film is nothing more than two points. The first is the content, and the second is the technical level. Content, to create more films accepted by the market and loved by the audience, technology should rely on all aspects of China industry, China economy and China society to promote the film industry. " Fu Ruoqing believes that with such a foundation, China films will surely have a bright future of high-quality development.


Five elements of healthy hotpot

  I don’t know when hot pot was labeled as "harmful to health". In fact, compared with traditional ordering, eating hot pot is more flexible and convenient in the selection and collocation of ingredients. As long as you pay attention to the following points, you can give consideration to health and delicious food.

  The bottom material is less salt and less oil. Eating hot pot, clear soup pot bottom with less salt and oil or mushroom soup pot bottom is the first choice. If they don’t taste good enough, you can also choose the bottom of the pot boiled with tomatoes or ketchup. If you like the bottom of the pot with spicy taste, it is recommended to skim off the Chili oil as much as possible before cooking the ingredients. If you still feel too greasy, you can prepare a small bowl of boiled water, dip the fished ingredients in water and eat them. People who love spicy food can also add appropriate peppers to their own small saucers.

  The ingredients are balanced. Eating hot pot is easy to diversify the ingredients, and most of the ingredients can be eaten by rinsing, such as green leafy vegetables, mushrooms, bean products, fish and shrimp, red meat, potatoes and so on. In addition, we should also pay attention to the balanced collocation between various ingredients. To eat one serving of meat, we need at least two servings of vegetables to match it, and it is best to eat vegetables while eating meat. It should be reminded that visceral foods such as pig brain are very delicious, but the cholesterol is much higher than that of normal red meat (lean pork contains 81 mg of cholesterol per 100 grams, lean beef is 58 mg, and pig liver, cow brain and pig brain are 288 mg, 2447 mg and 2571 mg respectively), so the frequency and amount of eating must be as little as possible, especially for people with hyperlipidemia.

  Dip in spices. Whether it is sesame sauce leek flower material or sesame oil garlic juice material, the fat content is very considerable. And most dip materials have high salt content, and there are various freshness-enhancing umami agents. After a hot pot, eat two small bowls of dip, and it is likely that the oil and salt are far beyond the standard. To rinse hot pot, you can use spice ingredients such as millet pepper, ginger, coriander, lime, garlic and other traditional dipping materials, which can not only reduce the intake of oil and salt, but also ensure that the dipping materials are tasty enough.

  Drinks are low in sugar at room temperature. Eating hot pot is easy to eat and eat more, so don’t make sugary drinks "worse". Try to choose boiled water for drinks, or you can choose sugar-free or low-sugar lemonade, light tea, soybean milk and so on. In addition, many people think it will be more refreshing to drink a large glass of iced drink while eating hot pot. But such a cold and a hot will strongly stimulate the stomach, and even lead to stomach cramps or stomachaches. Therefore, eat hot pot and drink less iced drinks, and choose some warm herbal tea or vegetable protein drinks.

  Rinse potatoes first. When you start to rinse the pot, after skimming the floating oil at the bottom of the pot, rinse potatoes, yams, sweet potatoes and other potatoes that can be used as vegetables and staple foods to protect the gastrointestinal tract; Eating vegetables early can increase satiety in advance, otherwise, not only the satiety is not strong, but also the intake of too much oil and purine. If it is a mandarin duck pot, try to rinse the vegetables on the side of the broth to avoid excessive oil intake. In addition, the delicious hot pot soup after rinsing is the favorite of many people. As everyone knows, a lot of purine has been dissolved in this soup, and drinking too much may cause gout. There are also seafood, sauerkraut pot bottom, nitrite content is not low, which is harmful to health. Therefore, it is best not to drink hot pot soup cooked for a long time. ▲

Examination Center of Ministry of Education: In July, some overseas examinations such as IELTS and TOEFL were resumed.

  On June 29th, the Examination Center of the Ministry of Education issued a notice on adjusting overseas exams in July 2020: some overseas exams such as IELTS and TOEFL will be resumed in July. The details of the notice are as follows:

  According to the situation of epidemic prevention and control in COVID-19 and the actual situation of overseas examination centers, after studying and consulting the relevant overseas examination organizers, it is decided to make the following adjustments to the overseas examination in July:

  1. Resume the TOEFL test in Suzhou University, Yangzhou University, Ningbo University, Xi ‘an International Studies University, Shenzhen City University, Shanghai Middle School, Changzhou Senior Middle School, Dongguan Wensheng International School, Suzhou International Preparatory School and Shenzhen SEG Talent Training Center from July 11th (there are 10 test sites, and the TOEFL test on July 4th and 5th will be cancelled, and the test fee will be fully refunded to the candidates’ individual registration accounts). Other TOEFL test centers still do not have the conditions for group test, and their TOEFL test in July will continue to be cancelled, and the test fee will be fully refunded to the candidate’s personal registration account.

  2. Resume all computerized IELTS tests in Shanghai Computer Test Center, Guangzhou Computer Test Center and Chongqing Computer Test Center from July 9th (there are 3 computer test sites and 4 computer test sites); From July 11th, the IELTS paper-and-pencil tests in Suzhou University, Yangzhou University, Ningbo University, Xiamen University, Guangxi University, Xi ‘an International Studies University, Northwestern Polytechnical University, Shaanxi Normal University, Sichuan International Studies University, Chongqing University, Shijiazhuang Institute of Information Engineering and Shenzhen SEG Talent Training Center will be gradually resumed (there are 12 paper-and-pencil test centers, and the IELTS test before the retest date will be cancelled, and the test fee will be fully refunded to the candidates’ individual registration accounts. See the notice on the registration website for specific arrangements). Other IELTS test sites still do not have the conditions for group test, so the IELTS test in July will continue to be cancelled, and the test fee will be fully refunded to the candidate’s personal registration account.

  3. Resume the GRE examinations of Suzhou University, Yangzhou University, Ningbo University, Xi ‘an International Studies University, Shenzhen City University, Shanghai Middle School, Dongguan Wensheng International School and Shenzhen SEG Talent Training Center from July 12th (a total of 8 test sites). Other GRE test sites still do not have the conditions for group examination, and continue to cancel their GRE test in July, and the examination fee will be fully refunded to the candidate’s personal registration account.

  4. From July 9th, the GMAT examinations in Shanghai and Guangzhou, Suzhou University, Ningbo University, Xi ‘an International Studies University and Shenzhen SEG Talent Training Center will be resumed (the GMAT examinations in 6 test sites will be cancelled before July 9th, and the examination fees will be fully refunded to the candidates’ individual registration accounts). Other GMAT test sites still do not have the conditions for group examination, and their GMAT test in July will continue to be cancelled, and the examination fee will be refunded to the candidate’s personal registration account in full.

  5. Cancel the Telford exam held on July 4, 2020.

Cats in History-Cats in Ancient Egyptian, Jewish and Medieval Manuscripts

        "Cats’ shovel slave" has become a proud nickname for a large number of cat lovers. For many young artists, the elegance, charm and mystery of cats provide endless comfort and warmth for their lives. In history, cats, a mysterious creature, have also experienced the fate of being respected or slaughtered.

        According to a study in Science in 2007, there is almost no difference in gene arrangement between the subspecies of modern domestic cats and the wild cats in the Middle East, which proves that domestic cats really originated from the Middle East alone. Archaeologists once found a wild cat buried in a man’s cemetery about 9500 years ago in Cyprus, which provided some evidence for the early relationship between human beings and cats. In the ruins of Quanhu Village in China (Yangshao and Longshan Cultural Sites in Neolithic Age), eight bones of two cats dating back to 5,300 years have also been found. According to the collagen isotope analysis of their bones, the food of these two cats is mainly meat and millet, which proves that these cats are probably fed by humans.

        In the medieval and early modern history of Europe, there have been many large-scale massacres against cats, and they are often associated with witch hunting. Why did Christian culture in the late Middle Ages have such a strong hatred for cats?

        This story begins with the ancient Egyptian civilization in the Middle East, the birthplace of domestic cats.

The Best God of Ancient Egypt: the Golden Age of Cats

        Among ancient civilizations, the worship of cats by Egyptians was the most striking. In Egyptian mythology, the sun god Dora once turned into a cat, defeating the python Apophis, which prevented the sun from rising and setting in the west, so people regarded the cat as the incarnation of the god. As early as the second dynasty (2890 BC), the worship of the cat god Best appeared in Lower Egypt and the Nile Delta. In Upper Egypt, Sekhmet, the god of war and healing, mainly appeared as a lion-faced woman. After the unification of upper and lower Egypt, around the first Millennium BC, the God Best and the God Sehmet gradually merged and appeared as a cat-faced woman. Especially after the 18th dynasty of ancient Egypt moved its capital to Thebes, the image of the cat god Best became more fixed.

Cat god best

        With the popularity of domestic cats in Egypt, the image of their gods has gradually changed from the god of war to the god who guards their homes, but it still has the symbolic significance of Pharaoh defenders. For example, in the Middle Kingdom period, the statue of Best depicted a cat face, but it often attached a lion face mask to show its original wildness and strength.

        Herodotus, a Greek historian, visited babs in Egypt in 450 BC, leaving us a precious record of cat worship. He wrote that in this place, if you deliberately kill a cat, you will be sentenced to death; For manslaughter, a considerable amount of money should be compensated according to the requirements of the priestess. If the domestic cat dies (mostly due to food poisoning or being bitten by other wild animals), the whole family should shave their eyebrows to express their condolences, otherwise the best god will suffer.

        The dead cat will be sent to the temple to be mummified and buried. At the end of 19th century, a cat graveyard was found in Egypt, in which about 300,000 cats were buried. These cats were all painted with spices and mummified, and even there were mice and thread balls for cats to play in the tomb. In addition, in the event of a fire, if the ancient Egyptians saw a cat walking through the fire, they would hold a grand mourning ceremony, because it represented that the cat god was alleviating the disaster for others.

Cat Mummies in Ancient Egypt

        Domestic cats in ancient Egypt mainly prevented mice from stealing food. In addition, cats can also fight snakes, thus giving them a noble and mysterious power, which is also in line with the legend of pulling gods and fighting python in Egyptian mythology. In addition to catching mice, domestic cats often go hunting with their owners. In the British Museum, there is a picture of "Cats Hunting" in ancient Egypt.

        During the new dynasty, many women who want to have children will also wear amulets painted with the cat god Best, and the number of kittens depicted on the amulets represents the number of children they wish to have. By Ptolemy’s time, Egypt was gradually influenced by Hellenism, and Best, the cat god representing the moon, was also interpreted by the Greeks as a variant of Al themis. When the Romans occupied Egypt, especially the rise of Christianity, this pagan worship gradually disappeared.

"Cats Hunting Map" in British Museum

Cats in Jewish culture

        Some people think that the negative Christian view of cats comes from the fact that there is no record of this animal in the Bible. However, on closer examination, this explanation is far-fetched.

        Although there are no cats in the Bible, there have been many other big cats, especially lions and leopards. For example, in Genesis, Jacob, the Jewish ancestor, blessed his son Judas and said, "Judas is a lion cub; My son, you come up after hunting food, prostrate yourself like a lion and a lioness. Who dares to disturb you? "

        Some people think that cats are not recorded in the Bible because Egyptians worship cat gods, while Jews regard them as idolatry and do not record them. However, other animal gods worshipped by Egyptians are often recorded in the Bible. Some later generations explained that although Jews were imprisoned in Egypt for 400 years, they probably did not know the existence of domestic cats. Because the Egyptians regarded cats as gods, they were not easily contacted by Jews who were slaves. In addition, there were almost no cats in the early Greek and Roman civilization, and they didn’t know about the existence of domestic cats until they conquered Egypt.

Cats catching birds in Roman mosaic paintings

        It is worth noting that there is indeed a description of cats in the Talmud. One of them said, "If God had not promulgated the Torah for us, we would have learned humility from cats." (Eruvin, 100b) A 9th-century rabbi’s exegesis book records that cats’ modesty is mainly reflected in the fact that they often cover their faces. Moreover, cats have the habit of burying excrement and cleaning their bodies, which also makes Jews who like cleanliness regard them as virtue teachers in life.

        There are also negative records about cats in the Talmud. A rabbi’s student asked him why dogs know their owners, but cats can’t. The rabbi replied that because cats eat mice, their memory declines; The more mice cats eat, the worse their memory. However, in Jewish customs, there is no taboo about cats, especially black cats, in Christianity later.

Chapter "Ode to Domestic and Wild Animals" in Ode to the Universe

        Perek Shirah, a Jewish religious reading about the 10th century, depicts various scenes in which creatures praise the creator. Among them, the eulogy sung by cats comes from a famous sentence in the Psalms: "I pursued my enemies and captured them until they were wiped out and never returned." Obviously, the image of cats as hunters is still highly praised in Jewish culture.

        In the Middle Ages, Jews living in Gedu also kept cats, mainly to prevent mice from eating the Bible and stealing food. During the Black Death, the existence of domestic cats in Jewish communities also largely resisted the spread of plague. Of course, some studies have pointed out that Jews’ eating habits and living environment may protect them to a greater extent. Because in the late Middle Ages and early modern times, many people at the bottom of western Europe ate rat meat, which also provided more opportunities for fleas who spread plague, while Jews were often spared because of the clean diet law. However, these in turn strengthened the hatred of Jews and cats in Western Europe, believing that it was they who secretly spread the Black Death.

Cats in monasteries and manuscripts

        The Christian world was not hostile to cats from the beginning. In medieval monasteries, cats have always existed, and their figures have been preserved through medieval manuscripts. In addition to the collection of animal fables, the image of cats appears in the margins of medieval manuscripts, which is quite entertaining. According to the research of St. isidore, the origin of the Latin name (catus) of cats means "catching". Although this is not the case in etymology, it also shows that in the eyes of medieval people, the main function of cats is to catch mice, and they are endowed with the image of hunters.

        Rats have always been the natural enemies of books, and the traces of these small animals have survived for thousands of years through manuscripts.

A manuscript of the Comfort of Philosophy by Boethius bitten by a mouse Corpus Christi College Cambridge, MS 214, Fol. 122r.        

        The most unacceptable thing for people is that rats will chew the candles in the church and even steal the Eucharist (unleavened bread) placed in the Eucharist niche. This is a great blasphemy! In a collection of animal fables in the mid-13th century, it was described that big cats caught mice that ate the Eucharist.

The mouse steals the Eucharist, the cat catches the mouse, and at the bottom there is a cat who is playing an instrument, Harley MS 4751, F.30V.        

        In addition to eating manuscripts and stealing the Eucharist from the church, mice also ate the cheese of monks, which was quite expensive food in Europe at that time. In a medieval manuscript about the late 11th century, it depicts a mouse climbing onto the dining table and stealing Hildebert’s cheese. Hildebert holds a stone for killing. At the table, a big cat depicted as a lion is majestically guarding the manuscript copied by its owner. The most interesting thing is that when I carefully observed the manuscript spread out in front of Hildebert, I found that it was actually a curse on the mouse: "The meanest mouse, you often annoy me." Let God destroy you! " (Pessime mus, sepius me provocas ad iram; ut te deus perdat)

Hildebert and the cat and mouse, Prague, capitular library, codex a 21/1, fol.153r.      

        An Irish monk in the 9th century once wrote a touching poem for his cat. In his works, the kitten’s hunting life is integrated with his own academic exploration. The little white cat in the famous animated film The Secret of Kells comes from this poem called Pangur Bán (excerpt):

        Me and my little white cat Pangu,

        Engaged in similar affairs.

        Its fun is catching mice,

        I chased the words all night.

        

        The praise of the world,

        Far less than sitting alone with books and pens.

        ……

        How sweet this job is to us,

        How fascinated we are with this job.

        ……

        We find our own peace in our work,

        I have mine, my cat Pangu has its own, joy.

        In our respective arts, we find our own ecstasy,

        I have mine, it has its own.

        

        I’m practicing my skills day and night,

        Pangu is also perfecting its skills.

        My wisdom is growing day and night,

        Turn the long night into endless light.        

        However, not all cats are so unpopular. A 1445 manuscript left a cat paw print, and the owner of the manuscript must have been very upset at that time. However, this is not the most distressing thing. A manuscript written in about 1420 records the curse on cats, because the scribe found that cats peed in the manuscript he copied. Therefore, the scribe had to stop copying on this half page, and explained the reason and the warning to future generations: "There is nothing missing here, but a cat spilled urine on it one night." I’m going to curse the cat that peed on my book here in Fintel one night, and curse other cats because of it. Be careful not to leave the book open where the cat may sneak in. "

 

A medieval Italian manuscript with cat paw prints.

A page of manuscript destroyed by cat urine, Cologne, Historisches Archiv, G.B. Quarto, 249, Fol. 68R.

        

        In addition, in the depiction of the Middle Ages, cats were often associated with string players, which may be due to the similarity of their beards and strings. For example, in an early 14th century Book of Hours, several kittens were elegantly playing three-stringed instruments.

Cats playing musical instruments 1

Cats who play musical instruments 2